Restoration of cardiac function after anaemia-induced heart failure in zebrafish

Journal of Molecular and Cellular Cardiology
Isabelle ErnensYvan Devaux

Abstract

New therapeutic approaches are needed to fight against the growing epidemic of heart failure. Unlike mammals, zebrafish possess the incredible ability to regenerate cardiac tissue after acute trauma such as apical resection. Yet, the ability of zebrafish to recover after a chronic stress leading to heart failure has not been reported. The aim of this study was to test whether zebrafish can recover a normal cardiac function after anaemia-induced heart failure. Eight- to ten-month-old zebrafish were treated with phenylhydrazine hydrochloride, an anaemia inducer, to generate heart failure. Treatment was stopped after 5 weeks and fish were followed-up for 3 weeks. Assessment of ventricular function by ultrasound at the end of the treatment revealed an increase in ventricle diameter (+47%) and a decrease in heart rate (-36%) and fractional shortening (-30%). A decrease in swim capacity was also observed (-31%). Tissue staining showed a thickening of the ventricular wall (5-fold), cell apoptosis and proliferation but no fibrosis. Expression of foetal genes, angiogenic factor and inflammation markers was increased, and β-adrenergic receptor-1 was decreased. Three weeks after phenylhydrazine hydrochloride withdrawal, all parameters ret...Continue Reading

Citations

Aug 25, 2020·The Canadian Journal of Cardiology·Andrew I LumleyYvan Devaux
Sep 20, 2020·The Canadian Journal of Cardiology·David de Gonzalo-Calvo, Christian Bär
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Suneeta NarumanchiJere Paavola

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