Restoration of cefixime-induced gut microbiota changes by Lactobacillus cocktails and fructooligosaccharides in a mouse model

Microbiological Research
Ying ShiWei Chen

Abstract

Probiotics have been used to rebuild the antibiotic-induced dysfunction in gut microbiota, but whether the different strains of probiotics result in similar or reverse effects remains unclear. In this study, the different recovery effects of two cocktails (each contains four strains) of Lactobacillus and fructooligosaccharide against cefixime-induced change of gut microbiota were evaluated in C57BL/6J mice. The results show that the use of cefixime caused a reduction in the diversities of the microbial community and led to significantly decreasing to one preponderant Firmicutes phylum, which was difficult to restore naturally in the short term. The gut microbiota compositions of the groups treated with the probiotic cocktails were much more diverse than those of the natural recovery group. The effects of Lactobacillus cocktails against the cefixime-induced gut microbiota change may mainly be due to the beneficial SCFAs production in vivo and also be related to the good cell adhesion properties performed in vitro. Meanwhile, the restoration of the cefixime-induced gut microbiota was significantly different between two Lactobacillus groups since the Lactobacillus strains with high levels of fructooligosaccharide use and better ce...Continue Reading

Citations

Oct 13, 2020·Frontiers in Microbiology·Viviane Lima BatistaMariana Martins Drumond
Nov 18, 2020·Critical Reviews in Food Science and Nutrition·Hui DuanWei Chen
Mar 2, 2021·Food Research International·Jie LiXiaoping Yang
Nov 25, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yasmina Ait ChaitRiadh Hammami
Jun 3, 2021·International Journal of Molecular Sciences·Laura Marinela Ailioaie, Gerhard Litscher

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