PMID: 2110845Jan 22, 1990Paper

Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats

Brain Research
V HaroutunianK L Davis

Abstract

The effects of combined lesions of forebrain cholinergic and noradrenergic systems on memory and responsivity to the memory enhancing effects of cholinomimetics were investigated in rats. Forebrain noradrenergic deficits produced by the injection of 6-hydroxydopamine into the ascending noradrenergic bundle (ANB) blocked the ability of cholinomimetics such as physostigmine and oxotremorine to enhance retention test performance in nucleus basalis of Meynert lesioned rats. Low doses of the noradrenergic receptor agonist clonidine, when administered in conjunction with cholinomimetics reversed this blockade. These results suggest that combined cholinergic/noradrenergic therapy may be of value in the treatment of some Alzheimer's disease patients.

References

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Citations

Feb 14, 1992·Brain Research·M W DeckerD J Anderson
Jul 6, 1993·European Journal of Pharmacology·M OhnoS Watanabe
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·T OgasawaraK Kimura
Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·T OgasawaraK Kimura
Oct 16, 1995·Psychiatry Research·D B MarinK L Davis
Jan 1, 1995·Peptides·M MillerM Wiltshire-Clement
Dec 1, 1992·Brain Research Bulletin·C FrankA Scotti de Carolis
Oct 22, 2013·Journal of Bodywork and Movement Therapies·Nasrin HosseiniMaryam Radahmadi
Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Anthony C Santucci, Vahram Haroutunian
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W WallaceV Haroutunian
Jan 1, 1992·Acta Neurologica Scandinavica. Supplementum·C J FowlerR F Cowburn
Jan 5, 2005·Trends in Pharmacological Sciences·Moussa B H Youdim, Jerry J Buccafusco
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·A J DekkerL J Thal
Mar 1, 2012·Neurochemistry International·Ravichandran SrividhyaPeriandavan Kalaiselvi
Jul 6, 2004·The Journal of Comparative Neurology·John AntonopoulosAthanasios Dinopoulos
Dec 1, 1990·Neurochemical Research·H SoininenS Shillcutt
Mar 17, 2021·Brain : a Journal of Neurology·Negin HollandJames B Rowe

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