Restoration of descending inputs fails to rescue activity following deafferentation of a motor network

Journal of Neurophysiology
Jebun NaharDavid J Schulz

Abstract

Motor networks such as the pyloric network of the stomatogastric ganglion often require descending neuromodulatory inputs to initiate, regulate, and modulate their activity and their synaptic connectivity to manifest physiologically appropriate output. Prolonged removal of these descending inputs often results in a compensatory response that alters the inputs themselves, their targets, or both. Using the pyloric network of the crab, Cancer borealis, we investigated whether isolation of motor networks would result in alterations that change the responses of these networks to restored modulatory input. We used a reversible block with isotonic sucrose to transiently alter descending inputs into the pyloric network of the crab stomatogastric ganglion. Using this method, we found that blocking neuromodulatory inputs caused a reduced ability for subsequently restored modulatory projections to appropriately generate network output. Our results suggest that this could be due to changes in activity of descending projection neurons as well as changes in sensitivity to neuromodulators of the target neurons that develop over the time course of the blockade. These findings suggest that although homeostatic plasticity may play a critical rol...Continue Reading

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Citations

Oct 2, 2013·Brain : a Journal of Neurology·Janine BeauparlantGrégoire Courtine
Feb 6, 2015·Frontiers in Neural Circuits·Matthew I Becker, David Parker
Jul 28, 2016·Current Opinion in Neurobiology·Nelly DaurDirk Bucher
Mar 20, 2015·Journal of Neurophysiology·Cynthia M HarleyKaren A Mesce

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