PMID: 2493970Jan 1, 1989Paper

Restoration of DNA supercoiling in fibroblasts in the rat subjected to gamma ray or fast neutrons

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
Nicole GiocantiB Ekert

Abstract

Nucleoid sedimentation analysis was applied to the study of DNA supercoiling repair in cultured FR 3T3 fibroblasts exposed to low doses of fast neutrons or gamma-rays. Supercoiling was fully restored in both instances upon post-irradiation at 37 degrees C, but the rate of repair of neutron-induced lesions was lower than that for gamma-rays. Non-repairable breaks were not evidenced at the neutral pH used. We suggest that the non-repairable alkali-labile sites evidenced by others in neutron-irradiated DNA do not prevent strand break rejoining and subsequent recovery of the tertiary DNA structure.

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