Abstract
Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage (MO/Mphi) surfaces in head and neck squamous cell carcinoma (HNSCC) patients (stage IIIB). Ligands (RANTES, MIP-1alpha and MIP-1beta) of this chemokine receptor were also secreted in lesser quantity from MO/Mphi of HNSCC patients in comparison with healthy individuals. In an aim to restore this dysregulated receptor-ligand signaling, we have used neem leaf glycoprotein (NLGP), a novel immunomodulator reported from our laboratory. NLGP upregulated CCR5 expression, as evidenced from studies on MO/Mphi of peripheral blood from HNSCC patients as well as healthy individuals. Expression of RANTES, MIP-1alpha and MIP-1beta was also upregulated following NLGP treatment of these cells in vitro. Interestingly, NLGP has little effect on the expression of CCR5 and the ligand RANTES in oral cancer cells. This restored CCR5 receptor-ligand signaling seen in MO/Mphi was reflected in improved CCR5-dependent, p38 mitogen-activated protein kinase (MAPK)-mediated migration of MO/Mphi after NLGP treatment to a standard chemoattractant. NLGP also induces better antigen presentation and simultaneous costimulation to effector T cells by MO/Mphi by ...Continue Reading
References
Mar 19, 1996·Biochemistry·M SamsonM Parmentier
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·C C BleulC R Mackay
May 5, 1997·The Journal of Experimental Medicine·L WuC R Mackay
Dec 13, 1997·Nature Medicine·M ZaitsevaH Golding
Mar 21, 1998·The Journal of Clinical Investigation·S QinC R Mackay
Apr 29, 1998·Nature·M Baggiolini
Mar 29, 2001·Nature Immunology·B Moser, P Loetscher
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephan LangReinhard Zeidler
Mar 24, 2004·International Immunopharmacology·Rathindranath Baral, Utpala Chattopadhyay
Apr 15, 2004·Immunology Letters·Lilach Goldberg-BittmanAdit Ben-Baruch
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tali FefermanMiriam C Souroujon
Jun 15, 2007·Phytotherapy Research : PTR·Anamika BoseRathindranath Baral
Jun 16, 2007·Cancer Immunology, Immunotherapy : CII·Diego O CrociO Graciela Scharovsky
Oct 27, 2007·Human Immunology·Anamika Bose, Rathindranath Baral
Jan 1, 2008·Cellular Signalling·Fabrizio MontecuccoLuciano Ottonello
Jan 10, 2008·International Immunopharmacology·Krishnendu ChakrabortyRathindranath Baral
Jan 10, 2008·Journal of Vascular Research·Hwan Myung LeeBokyung Kim
Jul 2, 2008·Vaccine·Koustav SarkarRathindranath Baral
Aug 30, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Krishnendu ChakrabortyRathindranath Baral
Nov 6, 2008·Human Immunology·Anamika BoseRathindranath Baral
Jan 9, 2009·European Journal of Immunology·Franco ScaldaferriSilvio Danese
Mar 25, 2009·Journal of Immunotherapy·Anamika BoseRathindranath Baral
Apr 1, 2009·Journal of Cellular Physiology·Jing-Yuan ChuangChih-Hsin Tang
Citations
May 1, 2013·Human Immunology·Soumyabrata RoyRathindranath Baral
Jan 18, 2013·PloS One·Atanu MallickRathindranath Baral
Jun 21, 2013·PloS One·Subhasis BarikRathindranath Baral
Aug 17, 2011·Immunotherapy·Tathagata ChakrabortyRathindranath Baral
Jun 25, 2013·Expert Opinion on Biological Therapy·Vincent VarillaConstantin A Dasanu
Oct 8, 2014·Immunotherapy·Atanu MallickRathindranath Baral
Mar 13, 2014·Molecular Immunology·K K GoswamiR Baral
Jul 18, 2014·Journal of Neural Transmission·Sven SaussezMia Levite
Nov 13, 2014·PloS One·Saptak BanerjeeRathindranath Baral
Jun 25, 2016·Journal of Veterinary Internal Medicine·J L TuohyJ E Fogle
May 14, 2020·Journal of Cellular Physiology·Baoping XuYang Yang
Sep 25, 2019·Stem Cell Research & Therapy·Tithi GhoshAnamika Bose
May 1, 2021·3 Biotech·Subendu SarkarGorachand Bhattacharya
Apr 15, 2011·Current Opinion in Oncology