Restoration of endocrine function and fertility with a tubo-ovarian autotransplant as the anatomical-functional unit in rabbits using a vascular microsurgical technique

Transplantation Proceedings
Manuel M MerazE M Aburto

Abstract

Infertility has been considered a global public health problem in many countries worldwide. Our objective was to restore endocrine function and fertility in tubal-oophorectomized rabbits using an orthotopic tubal-ovarian vascularized autotransplant model as the anatomical-functional unit while employing a microvascular surgical technique. Twenty New Zealand white (NZW) sexually mature female rabbits and four male NZW rabbits of proven fertility were divided into two study groups. In group I (n = 10), a left salpingo-oophorectomy was performed. Group II (n = 10) was subjected to a bilateral salpingo-oophorectomy, plus a right orthotopic tubal-ovarian autotransplant. Our testing variables were vascular and tubal-anastomoses permeability, estradiol (E2) and progesterone (P4) serum levels, pregnancy, number of offspring, histopathological study of the uteri, fallopian tubes, and ovaries. One hundred percent immediate permeability of the tubal anastomoses was achieved, while late permeability was found to be 64%. Immediate permeability of vascular anastomoses was 90%, and late permeability was recorded at 80%. E2 serum levels in both groups at different times showed no statistically significant differences. In the case of P4, a smal...Continue Reading

References

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Citations

Jan 23, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Manuel M MerazEduardo Tena Betancour

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