Restoration of endocrine function and ovulation after a heterotopic ovarian transplant in the inguinal region of rabbits using a vascular microsurgical technique

Transplantation Proceedings
Manuel M MerazE M Aburto

Abstract

The aim of this study was to define an experimental model in rabbits for subcutaneous heterotopic ovarian autotransplants and allotransplants in the inguinal region using a microvascular technique to restore endocrine function and ovulation. Forty sexually mature New Zealand white receptor rabbits and 20 donating Californian rabbits were divided into two experimental models: model A; autogenic model-control group 1 (n = 10), right ovariectomy; group II (n = 10), heterotopic ovarian autotransplant with peritoneal pouch plus left ovariectomy; model B: allogenic model-donator group III (n = 10), right ovariectomy with peritoneal tissue; receptor group (n = 10), ovarian heterotopic allotransplant with peritoneal pouch and bilateral ovariectomy, without immunosuppression; group IV donator (n = 10), receptor (n = 10) using the same procedure as in group III, administering cyclosporine 4 mg/kg/d intramuscularly and prednisone 1 mg/kg/d PO for 28 days. Ovarian function was assessed in the transplanted ovary after stimulation with human chorionic gonadotropin (100 IU). Exfoliative vaginal cytology was done, serum estradiol (E2) and progesterone (P(4)) were measure, and a histological study of ovaries and uteri was done. Late vascular pe...Continue Reading

References

Aug 1, 1982·British Journal of Obstetrics and Gynaecology·R DenjeanI Brosens
Mar 12, 2005·Annual Review of Public Health·Elizabeth Barrett-ConnorMarcia L Stefanick
Apr 26, 2005·Transplantation Proceedings·Z Jabiry-ZieniewiczM Krawczyk
May 4, 2005·Lancet·Valerie BeralUNKNOWN Million Women Study Collaborators

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Citations

Jan 23, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Manuel M MerazEduardo Tena Betancour

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