Restoration of erect posture by deep brain stimulation of the globus pallidus in disabling dystonic spinal hyperextension

Journal of Neurosurgery
Damianos E SakasStylianos Gatzonis

Abstract

Dystonia is a movement disorder notoriously difficult to treat. While primary dystonia is classically considered to respond well to deep brain stimulation (DBS), treatment of secondary dystonia yields variable results. Patient selection should be done on a case-by-case basis. Clearly, there is a need to accumulate additional information with regard to prognostic factors that may aid neurosurgeons in selecting those patients in whom the disorder is most likely to respond favorably to pallidal DBS. The authors report the case of a 29-year-old man with secondary dystonia due to perinatal hypoxia. The most prominent symptom was what we have termed ectatocormia-that is, severe, fixed truncal hyperextension and retrocollis, exacerbated by phasic, twisting movements of the trunk and head. This made it impossible for the patient to maintain a normal upright posture or to walk. The patient underwent bilateral DBS of the globus pallidus internus (GPi), and the authors observed impressive improvement in motor abilities and function. The patient's body adopted the normal upright posture and he became able to walk again, 4 months after the commencement of GPi stimulation. This report, along with others, emphasizes that the GPi as an ideal t...Continue Reading

References

Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·John YianniTipu Aziz
May 23, 2003·Journal of Neurology·Andreas KupschThomas Trottenberg
Nov 19, 2005·Expert Review of Medical Devices·Michele TagliatiRon Alterman
Jun 21, 2006·Neurotoxicity Research·J Jankovic
Nov 4, 2006·Parkinsonism & Related Disorders·John Y K LeeAli Rezai
Feb 17, 2007·Lancet Neurology·Marie VidailhetUNKNOWN French SPIDY Study Group
Aug 19, 2007·Acta Neurochirurgica. Supplement·D E SakasG Tagaris
Mar 14, 2008·Journal of Neurology·T J LoherJ K Krauss
Jun 17, 2008·Journal of Computational Neuroscience·Xavier VasquesPhilippe Coubes
Jun 24, 2008·Brain : a Journal of Neurology·Ioannis U IsaiasMichele Tagliati
Dec 3, 2008·Journal of Neurosurgery·Damianos E SakasStylianos D Gatzonis

❮ Previous
Next ❯

Citations

Jul 9, 2011·Journal of the History of the Neurosciences·Ioannis G PanouriasDamianos E Sakas
Apr 11, 2012·Clinical Neurology and Neurosurgery·Michał SobstylWojciech Górecki
Feb 15, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Anne KoyLars Timmermann
Nov 21, 2019·Movement Disorders Clinical Practice·Karlo J Lizarraga, Alfonso Fasano
Jun 29, 2021·Frontiers in Human Neuroscience·Kantharuby TambirajooKeyoumars Ashkan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.