PMID: 8963036Sep 1, 1995Paper

Restoration of gap junctions in the regenerative process of ethanol-induced gastric mucosal injury

Journal of Gastroenterology and Hepatology
K EndoN Sato

Abstract

Gap junctions mediate intercellular communication and play an important role in cell proliferation and differentiation. The present study examined the expression of the gap junction protein connexin 32 in rat gastric mucosa during the regenerative process of ethanol-induced gastric mucosal injury. Absolute ethanol (0.5 mL/100 g bodyweight) was administered to rats via gastric intubation. Following the treatment, rats were killed periodically, and gastric tissues were processed for indirect immunofluorescence microscopy using an anti-connexin 32 antibody. Haematoxylin and eosin (H&E), periodic acid Schiff (PAS) and Bromodeoxyuridine (BrdU) staining were also performed in serial sections. Gastric injuries were limited in the mucosal layer. The injury was most severe 1 h after treatment, and was completely resolved by the 4th day after treatment. The number of immunoreactive spots for gap junctions was markedly decreased 1 h after the ethanol treatment. Reappearance of these immunostaining gap junctions occurred with repair of the injury. The reappearance of connexin 32 after injury was delayed in comparison with both the histologic resolution of the injury and the normalization of PAS-stained mucus. In contrast, the time course o...Continue Reading

References

Aug 1, 1978·The Journal of Cell Biology·A G Yee, J P Revel
Sep 1, 1978·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·H Okamoto, K Ishimura
Jan 1, 1991·Journal of Clinical Gastroenterology·A TarnawskiH Gergely
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May 1, 1993·Gastroenterologia Japonica·T Arakawa, K Kobayashi

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Citations

Jul 27, 2007·The Journal of Membrane Biology·Maria Lúcia Zaidan Dagli, Francisco Javier Hernandez-Blazquez
Sep 1, 1995·Journal of Gastroenterology and Hepatology·A Tarnawski, I J Sarfeh
Jun 19, 2015·Cellular and Molecular Life Sciences : CMLS·Michaël MaesMathieu Vinken
Sep 25, 2003·Physiological Reviews·Juan C SaezEric C Beyer

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