Restoration of immunocyte functions by thymosin alpha1 in cyclophosphamide-induced immunodeficient mice

Immunopharmacology and Immunotoxicology
H OhmoriN Kanayama

Abstract

Thymosin alpha1 (Talpha1) is an oligopeptide hormone originally isolated from the thymus gland, and has been reported to have stimulating effects on the differentiation of T cells and NK cells. These immunostimulating properties have been considered to be useful for improving immune disorders associated with various diseases including cancer, AIDS and hepatitis. Here, we characterized immunostimulating properties of Talpha1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY). Repeated injection of 30-300 microg/kg/day of Talpha1 after CY-treatment significantly accelerated the restoration of the reduced number of CD4+CD8+ T cells in the thymus. Talpha1 administration was effective in restoring the suppressed activities of helper T cells and cytotoxic T cells in CY-treated mice. Talpha1 also had stimulating effects on reduced activity of lymphokine-activated killer cells in CY-treated mice. These results indicate that Talpha1 is stimulatory for both humoral and cellular immune responses, thus providing the immunological basis for the clinical benefit of this compound.

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Citations

Aug 30, 2003·Immunology Letters·Jolanta ArtymMarian L Kruzel
Feb 13, 2003·Toxicology·Karin CederbrantJacques Descotes
Apr 12, 2017·The Journal of Pharmacy and Pharmacology·Tatiana V BomkoArtur V Martynov
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Hironori IshibashiHironobu Sasano
Mar 6, 2004·International Journal of Immunopathology and Pharmacology·P ShrivastavaN Singh
Aug 17, 2005·Cancer Investigation·Pratima ShrivastavaNisha Singh
Aug 19, 2004·Journal of Biomedical Science·Pratima ShrivastavaNisha Singh
Aug 14, 2015·Journal of Immunotoxicology·Michał ZimeckiStanisław Ryng

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