PMID: 6969335Jan 1, 1980Paper

Restoration of impaired immune functions in aging animals. IV. Action of 2-mercaptoethanol in enhancing age-reduced immune responsiveness

Mechanisms of Ageing and Development
M L HeidrickT Makinodan

Abstract

The enhancing effect of 2-mercaptoethanol (2-ME) on the immune responses of young and old unseparated spleen cells and purified populations of T-cells, B-cells and macrophages was studied. While 2-ME enhances both the normal responses of young cells and the age-reduced responses of old cells, the sulfhydryl compound has a relatively greater enhancing effect on old spleen cells in the humoral response to sheep red blood cells and the blastogenic response to concanavalin A (Con A). The greater enhancing effect in the humoral response appears to be due to 2-ME overcoming a suppressive effect of old T-cells which develops with increasing age. The greater enhancing effect in Con A stimulation appears to be an effect on the Con A responsive sub-population of T-cells and not on the synergistic effect of the presence of B-cells.

References

Jan 1, 1979·Mechanisms of Ageing and Development·T Makinodan
Apr 1, 1977·The Journal of Experimental Medicine·H G OpitzH D Flad
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Apr 1, 1974·The Journal of Experimental Medicine·M J BevanM Cohn
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Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
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Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

Jul 1, 1981·Molecular and Cellular Biochemistry·D L DoggettB L Strehler
Oct 1, 1988·Mechanisms of Ageing and Development·L PénzesO Regius
Oct 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D W PorterW G Martin
Jan 1, 1988·Experimental Aging Research·D G Hazzard, J Soban
May 1, 1992·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·B LarssonC Fossum
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·E Papadopulos-EleopulosA P Dufty
Jun 1, 1982·Cellular Immunology·E H PerkinsP L Glover
Mar 1, 1988·Medical Hypotheses·E Papadopulos-Eleopulos
Mar 14, 2007·The Journal of the Acoustical Society of America·Laura J May-Collado, Douglas Wartzok
Sep 22, 2020·Future Microbiology·Robert E Click

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