Restoration of Neurological Function Following Peripheral Nerve Trauma

International Journal of Molecular Sciences
Damien P Kuffler, Christian Foy

Abstract

Following peripheral nerve trauma that damages a length of the nerve, recovery of function is generally limited. This is because no material tested for bridging nerve gaps promotes good axon regeneration across the gap under conditions associated with common nerve traumas. While many materials have been tested, sensory nerve grafts remain the clinical "gold standard" technique. This is despite the significant limitations in the conditions under which they restore function. Thus, they induce reliable and good recovery only for patients < 25 years old, when gaps are <2 cm in length, and when repairs are performed <2-3 months post trauma. Repairs performed when these values are larger result in a precipitous decrease in neurological recovery. Further, when patients have more than one parameter larger than these values, there is normally no functional recovery. Clinically, there has been little progress in developing new techniques that increase the level of functional recovery following peripheral nerve injury. This paper examines the efficacies and limitations of sensory nerve grafts and various other techniques used to induce functional neurological recovery, and how these might be improved to induce more extensive functional re...Continue Reading

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Citations

Dec 4, 2020·Artificial Organs·Qingshan LongFeng Xu
Mar 7, 2021·Nanomaterials·Olga Y AntonovaYuri M Shlyapnikov
Jul 22, 2021·European Journal of Pain : EJP·Yohann BohrenEric Salvat
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Jingxin ZhangShiwen Zhang
Sep 21, 2021·Hand Surgery and Rehabilitation·Jefferson Braga SilvaBruna Leiria Meréje Leal

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