Restoration of proximal periprosthetic bone loss by denosumab in cementless total hip arthroplasty

European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie
Satoshi NagoyaToshihiko Yamashita

Abstract

Denosumab contributed to the restoration of proximal periprosthetic bone loss around the femoral stem that were measured using a DEXA, especially in zone 7, at 1 year after cementless THA in elderly osteoporotic patients. Although bone quality is an important issue in elderly osteoporotic patients who underwent total hip arthroplasty (THA) with a cementless stem, periprosthetic bone mineral density (BMD) in the proximal femur has been reported to be decreased by 15-40% postoperatively. Some authors have examined the use of several types of bisphosphonates to prevent decreases in BMD in the proximal femur after cementless THA; however, few reports have demonstrated success in restoring BMD in the proximal medial femoral bone, such as zone 7. We conducted prospective study comparing patients who underwent cementless THA administered with denosumab (10 patients) and without denosumab (10 patients). BMD around the femoral stem were measured using a DEXA immediately after surgery, and at 6 months and at 1 year after surgery. No difference was found between the two groups referred to the patient's demographic data. We found that denosumab displayed definitive effects in increasing the % change in periprosthetic BMD at zone 7 by an av...Continue Reading

References

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Dec 10, 2014·International Orthopaedics·Samo K FokterAlenka Repše-Fokter

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Citations

Oct 8, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Andreas NyströmHans Mallmin
Aug 1, 2020·Current Osteoporosis Reports·Kyle D AndersonRyan D Ross
May 23, 2020·BMC Musculoskeletal Disorders·Koji NozakaYoichi Shimada
Dec 4, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Giuseppe ToroAlfredo Schiavone Panni
Jun 19, 2021·Hip & Pelvis·Se-Won LeeHwan-Hee Lee

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