Restoration of SHIP-1 activity in human leukemic cells modifies NF-kappaB activation pathway and cellular survival upon oxidative stress

Oncogene
Geoffrey GloireJacques Piette

Abstract

Nuclear factor-kappa B (NF-kappaB) is an important prosurvival transcription factor activated in response to a large array of external stimuli, including reactive oxygen species (ROS). Previous works have shown that NF-kappaB activation by ROS involved tyrosine phosphorylation of the inhibitor IkappaBalpha through an IkappaB kinase (IKK)-independent mechanism. In the present work, we investigated with more details NF-kappaB redox regulation in human leukemic cells. By using different cell lines (CEM, Jurkat and the subclone Jurkat JR), we clearly showed that NF-kappaB activation by hydrogen peroxide (H2O2) is cell-type dependent: it activates NF-kappaB through tyrosine phosphorylation of IkappaBalpha in Jurkat cells, whereas it induces an IKK-mediated IkappaBalpha phosphorylation on S32 and 36 in CEM and Jurkat JR cells. We showed that this H2O2-induced IKK activation in CEM and Jurkat JR cells is mediated by SH2-containing inositol 5'-phosphatase 1 (SHIP-1), a lipid phosphatase that is absent in Jurkat cells. Indeed, the complementation of SHIP-1 in Jurkat cells made them shift to an IKK-dependent mechanism upon oxidative stress stimulation. We also showed that Jurkat cells expressing SHIP-1 are more resistant to H2O2-induced ...Continue Reading

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·M T AndersonL A Herzenberg
Nov 1, 1996·Biochemical Society Transactions·A L DrayerC Erneux
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·C BéraudP A Baeuerle
Mar 4, 2000·Free Radical Biology & Medicine·R G Allen, M Tresini
Mar 25, 2000·Molecular and Cellular Biology·S LemayA Veillette
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SchoonbroodtJ Piette
Sep 21, 2000·Seminars in Immunology·G Krystal
Feb 12, 2002·Photochemistry and Photobiology·Cédric VolantiJacques Piette
Jun 1, 2002·Science·Lewis C Cantley
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robin W FreeburnStephen G Ward
Jun 7, 2003·Advances in Enzyme Regulation·Katrien BackersChristophe Erneux
May 6, 2004·Annals of the New York Academy of Sciences·Maria Luisa GenovaGiorgio Lenaz
Jun 9, 2004·Free Radical Biology & Medicine·David A Hildeman
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huiqing FangSusheela Tridandapani
Oct 20, 2004·The Journal of Biological Chemistry·Michael G TomlinsonArthur Weiss

❮ Previous
Next ❯

Citations

Jun 12, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Marcin M KamińskiKarsten Gülow
Oct 6, 2007·Immunologic Research·Masaki KashiwadaPaul B Rothman
Sep 8, 2012·Cell Death and Differentiation·C-H JiaX-C Bai
Feb 11, 2009·Antioxidants & Redox Signaling·Geoffrey Gloire, Jacques Piette
Jan 5, 2011·Antioxidants & Redox Signaling·Regina Brigelius-Flohé, Leopold Flohé
Feb 23, 2011·Antioxidants & Redox Signaling·Jingjun LuJawahar L Mehta
Mar 23, 2011·Biochemistry. Biokhimii︠a︡·A O Zheltukhin, P M Chumakov
May 24, 2012·Oxidative Medicine and Cellular Longevity·Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Oct 9, 2012·American Journal of Respiratory Cell and Molecular Biology·Alice HuertasSunita Bhattacharya
Feb 25, 2011·PloS One·Jessica Q HoGourisankar Ghosh
Jan 29, 2016·Redox Biology·Fulvio UrsiniHenry Jay Forman
Sep 10, 2013·Surgical Oncology Clinics of North America·Derek J Erstad, James C Cusack
Dec 25, 2007·Advances in Enzyme Regulation·Marie-Pierre GratacapBernard Payrastre
Oct 9, 2007·Biochemical Pharmacology·Florence FolmerMarc Diederich
May 25, 2006·Photochemistry and Photobiology·Jean-Yves MatrouleJacques Piette
Feb 3, 2007·Muscle & Nerve·Jennifer S Moylan, Michael B Reid
Jul 19, 2006·Biochemical Pharmacology·Geoffrey GloireJacques Piette
May 26, 2006·Biochemical Pharmacology·Geoffrey GloireJacques Piette
Jun 25, 2013·Free Radical Biology & Medicine·Shotaro Nakajima, Masanori Kitamura
Sep 29, 2009·Biochimica Et Biophysica Acta·Richard V ParryStephen G Ward
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ataru NishimuraTakanari Kitazono
Mar 11, 2009·Human & Experimental Toxicology·Cl BassiE T Sakamoto-Hojo
Apr 2, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer A BallStephen G Ward
Oct 31, 2006·Oncogene·T D Gilmore, M Herscovitch
Oct 21, 2006·International Journal of Impotence Research·J Y JeremyN Shukla
Dec 13, 2007·The Journal of Biological Chemistry·Stephanie J HarrisStephen G Ward
Mar 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie J HarrisStephen G Ward
Mar 21, 2007·Biochemical Society Transactions·G GloireJ Piette
Jan 27, 2017·Journal of Cell Science·Thomas S Lisse, Sandra Rieger
Jun 1, 2007·The Journal of Biological Chemistry·Geoffrey GloireJacques Piette

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis