Restoration of synthesis of sulfoglucuronylglycolipids in cerebellar granule neurons promotes dedifferentiation and neurite outgrowth.

The Journal of Biological Chemistry
D K ChouF B Jungalwala

Abstract

Sulfoglucuronyl carbohydrate (SGC) linked to the terminal moiety of neolacto-oligosaccharides is expressed in several glycoproteins of the immunoglobulin superfamily involved in neural cell-cell recognition as well as in two sulfoglucuronylglycolipids (SGGLs) of the nervous system. SGGLs and SGC-containing glycoproteins are temporally and spatially regulated during development of the nervous system. In the cerebellum, the expression of SGC, particularly that of SGGLs, is biphasic. Several studies have suggested that the initial rise and decline in the levels of SGGLs and SGC-containing proteins correlated with the migration of granule neurons from the external granule cell layer to the internal granule cell layer and their subsequent maturation, whereas the later rise and continued expression of SGGLs in the adult was associated with their localization in the Purkinje neurons and their dendrites in the molecular layer. Here it is shown by immunocytochemical methods that the expression of SGC declined progressively in granule neurons isolated from cerebella of increasing age. The decline in the expression of SGC in granule neurons was also shown with time in culture. These results correlated with the previously shown declining a...Continue Reading

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Citations

Apr 25, 2000·Brain Research. Developmental Brain Research·Z ZhaoF B Jungalwala
May 15, 2007·Molecular and Biochemical Parasitology·Malena LandoniAlicia S Couto
Apr 10, 1999·The Journal of Biological Chemistry·R MiuraY Yamaguchi
Jul 18, 2020·CNS Neuroscience & Therapeutics·Hang Yeon JeongSung-Hak Kim

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