Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase

Life Sciences
Rita BenkoCsaba Szabó

Abstract

Oxidant-mediated activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) plays a role in the development of endothelial dysfunction and the pathogenesis of various cardiovascular diseases. The aim of the current study was to investigate whether activation of PARP contributes to the development of endothelial dysfunction in the apolipoprotein E (ApoE) deficient mice. We tested whether PARP inhibition prevents the development of endothelial dysfunction and whether it restores function in vessels with established endothelial dysfunction. ApoE deficient mice were kept on high-fat diet for 12 weeks with and without INO-1001 treatment. Chronic treatment with the PARP inhibitor INO-100 reduced the degree of the endothelial dysfunction (the ability of the vessel to relax to acetylcholine) in the thoracic aortae of ApoE deficient mice. In addition, in vitro incubation of vessels from ApoE deficient mice with established endothelial dysfunction with the PARP inhibitor acutely improved the ability of the rings to relax to acetylcholine. We conclude that the early atherosclerotic functional alterations that develop in the endothelium of the ApoE deficient mice are, at least in part, reversible, and are dependent on the activati...Continue Reading

References

Aug 15, 1998·Trends in Pharmacological Sciences·C Szabó, V L Dawson
Sep 12, 2000·Current Hypertension Reports·G Wolf
Mar 22, 2002·British Journal of Pharmacology·Pál PacherCsaba Szabó
Sep 12, 2002·Pharmacological Reviews·László Virág, Csaba Szabó
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Doris M ThamJohn C Rutledge
Mar 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Takuya MatsumotoZvonimir S Katusic
Jul 23, 2003·British Journal of Pharmacology·Fan JiangGregory J Dusting
Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Gábor SzabóAlexander Juhász-Nagy
Mar 27, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Chunxiang ZhangLisa K Jennings

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Citations

May 26, 2011·Basic Research in Cardiology·Wim MartinetGuido R Y De Meyer
Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo
May 3, 2005·Nature Reviews. Drug Discovery·Prakash Jagtap, Csaba Szabó
Feb 22, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Oded N SpindelBradford C Berk
Feb 15, 2012·Journal of Biomedical Science·Elisardo C VasquezSilvana S Meyrelles
Nov 16, 2011·Lipids in Health and Disease·Silvana S MeyrellesElisardo C Vasquez
Jun 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Levente KissZsombor Lacza
Feb 28, 2013·International Journal of Molecular Sciences·Tiziana CervelliMaria Grazia Andreassi
Dec 25, 2013·Biochimica Et Biophysica Acta·Magdolna SzántóPéter Bai
Oct 2, 2012·FEBS Letters·Péter Bai, László Virág
Apr 27, 2010·Biochemical Pharmacology·Vincenzo GiansantiA Ivana Scovassi
Jun 25, 2009·Biochemical Pharmacology·Simon G HelyarJon G Mabley
Nov 18, 2005·Biochemical and Biophysical Research Communications·Harald J J MoonenGeja J Hageman
Oct 1, 2013·Atherosclerosis·Andrea BorghiniMaria Grazia Andreassi
Oct 11, 2011·Biochemical and Biophysical Research Communications·Cathérine GebhardFelix C Tanner
Feb 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Marlene T Mathews, Bradford C Berk
Oct 26, 2018·Hypertension·Rhéure Alves-Lopes, Rhian M Touyz
Nov 10, 2013·Cancers·Amanda F SwindallEddy S Yang
Aug 28, 2021·Progress in Lipid Research·Magdolna SzántóPeter Bai

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