Restoration of visual responses following transplantation of intact retinal sheets in rd mice

Experimental Eye Research
S AraiSriniVas R Sadda

Abstract

To correlate the functional outcomes with histologic findings following transplantation of fetal retinal sheets in rd mice, and to investigate the mechanisms of visual function restoration. Twenty-one postnatal day 31-38 rd/rd (C3H/HeJ) mice were transplanted in one eye with retinal sheets (1.0 x 0.4 mm) obtained from embryonic day (E) 17 enhanced-green-fluorescent protein (eGFP) mice. Five mice underwent sham surgery without insertion of tissue. Four to five weeks after transplantation, visual responses to a light flash were recorded across the superior colliculus (SC) in seven eyes of seven transplanted mice that had clear corneas and lenses, and in all five sham surgery mice. Following the SC recording, the eyes were enucleated and processed for immunohistochemistry and examined using confocal microscopy. In three out of the seven eyes (43%), positive responses were recorded in the SC in an area topographically corresponding to the placement of the transplant in the host retina. No responses were recorded in the untreated eyes of 5-week-old and 9-week-old rd/rd mice, and in the 9-week-old sham surgery mice. In contrast, visual responses were recorded over the entire SC in normal eyes. The response onset latencies of the 3 tr...Continue Reading

References

Sep 1, 1991·Neuroreport·M del CerroC del Cerro
Oct 1, 1991·Experimental Eye Research·B EhingerA R Adolph
Oct 31, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·S Sanyal, A K Bal
Aug 1, 1966·The Journal of Comparative Neurology·R SiminoffL Kruger
Dec 1, 1982·Experimental Eye Research·J J PlantnerE L Kean
Jun 1, 1995·Experimental Neurology·R B Aramant, M J Seiler
Jul 1, 1994·Journal of Neural Transplantation & Plasticity·A R AdolphA Bergström
Jan 15, 1997·Microscopy Research and Technique·M del CerroD Diloreto
Sep 23, 1997·Archives of Ophthalmology·H J KaplanL V Del Priore
Nov 19, 1997·Journal of Neuroscience Research·J F McGinnisV Lerious
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Mohand-SaidJ A Sahel
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·T LiE L Berson
Jul 9, 1999·Vision Research·M S HumayunS Suzuki
Sep 16, 1999·Experimental Neurology·A S KwanR D Lund
Feb 2, 2000·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J D WeilandN T Iliff
Mar 17, 2000·Science·V TropepeD van der Kooy
Jun 24, 2000·Archives of Ophthalmology·S Mohand-SaidJ A Sahel
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Strettoi, V Pignatelli
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·D VollrathM M LaVail
Mar 22, 2002·Progress in Retinal and Eye Research·Robert B Aramant, Magdalene J Seiler
Aug 6, 2002·Survey of Ophthalmology·Eyal MargalitMark S Humayun
Dec 31, 2002·Investigative Ophthalmology & Visual Science·Yiqin ZhangMaria-Thereza R Perez
Jan 31, 2003·Investigative Ophthalmology & Visual Science·Anne-Claire FintzJosé Sahel
Feb 13, 2003·Ophthalmology·Adam S BergerHenry J Kaplan
Mar 27, 2003·Investigative Ophthalmology & Visual Science·Botir T SagdullaevMaureen A McCall
Apr 2, 2003·Vision Research·Enrica StrettoiBenedetto Falsini
Apr 17, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter Gouras, Teruyo Tanabe
Jun 5, 2003·Current Opinion in Ophthalmology·Rohit R LakhanpalMark S Humayun
Jul 17, 2003·The Journal of Comparative Neurology·Bryan W JonesRobert E Marc
Aug 2, 2003·Progress in Retinal and Eye Research·Robert E MarcEnrica Strettoi
Oct 7, 2003·Annual Review of Neuroscience·Laura R PacioneRoderick R McInnes
Jun 9, 2004·Experimental Eye Research·Biju B ThomasRobert B Aramant

❮ Previous
Next ❯

Citations

Oct 31, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Fredrik GhoshRobert M Petters
Oct 4, 2007·Cell and Tissue Research·Meta W Djojosubroto, Yvan Arsenijevic
Jan 19, 2005·The European Journal of Neuroscience·Magdalene J SeilerRobert B Aramant
Mar 22, 2013·Indian Journal of Ophthalmology·Sundaram Natarajan
Apr 5, 2005·Seminars in Ophthalmology·Magdalene J Seiler, Robert B Aramant
Sep 21, 2007·Current Eye Research·Qing PengMagdalene J Seiler
Jul 10, 2012·Progress in Retinal and Eye Research·Magdalene J Seiler, Robert B Aramant
Jul 30, 2008·The European Journal of Neuroscience·Magdalene J SeilerRobert B Aramant
Oct 25, 2007·Journal of Biomedical Materials Research. Part a·A Tezcaner, D Hicks
May 19, 2012·The European Journal of Neuroscience·M J SeilerR E Marc
Jan 29, 2010·The European Journal of Neuroscience·M J SeilerH S Keirstead
Jun 27, 2015·Progress in Retinal and Eye Research·Hossein NazariMark S Humayun
May 8, 2010·Journal of Neuroscience Methods·Gabriel NistorHans S Keirstead
Aug 8, 2009·Progress in Brain Research·Gerald J ChaderMark S Humayun
Sep 2, 2010·Experimental Eye Research·Pamela B YangHans S Keirstead
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Mandeep S Singh, Robert E MacLaren
May 9, 2009·Current Opinion in Ophthalmology·Paul S Baker, Gary C Brown
Mar 14, 2007·Médecine sciences : M/S·Thierry LéveillardJosé-Alain Sahel
Jul 13, 2018·Therapeutic Advances in Ophthalmology·Julia Oswald, Petr Baranov
Jul 30, 2019·Progress in Retinal and Eye Research·Rebecca L PfeifferBryan William Jones
Oct 24, 2020·International Ophthalmology Clinics·Jodi C HwangJayanth Sridhar
Mar 20, 2021·Molecular Therapy. Methods & Clinical Development·Anna SalasJosé García-Arumí

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Related Papers

Progress in Retinal and Eye Research
Robert B Aramant, Magdalene J Seiler
The European Journal of Neuroscience
Magdalene J SeilerRobert B Aramant
Progress in Retinal and Eye Research
Robert B Aramant, Magdalene J Seiler
© 2021 Meta ULC. All rights reserved