Restoring lower limb blood flow improves conduction velocity in diabetic patients

Diabetologia
M J YoungA J Boulton

Abstract

Human diabetic peripheral neuropathy is believed to have, at least in part, a microvascular basis. This study was designed to examine the effects of restoration of arterial blood supply on peripheral nerve function in six non-insulin-dependent diabetic patients with peripheral occlusive vascular disease. In the revascularised legs, transcutaneous oxygen increased from a median 37.5 (28.5-45.7 interquartile range) mmHg to 55.5 (53.5-62.5) mmHg, p = 0.036, mean increase 20.2 (14.8-25.6, 95% confidence intervals(CI) mmHg. This was accompanied by a significant improvement in peroneal motor nerve conduction velocity from 31.7 (26.5-36.3) m/s to 33.5 (32.9-39.4) m/s, p = 0.04, mean increase 4.7 (1.7-7.7, 95% CI) m/s. There was no significant change in transcutaneous oxygen or peroneal nerve motor conduction velocity in the contralateral control limbs. This improvement in conduction velocity with improved tissue oxygenation suggests that studies of agents which might indirectly bring about improvements in microvascular blood flow should be urgently considered.

References

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Citations

Jul 17, 2008·Archives of Dermatological Research·Aleksandar Janković, Ivana Binić
Dec 20, 2003·Current Neurology and Neuroscience Reports·David Podwall, Clifton Gooch
Nov 3, 2004·The Neurologist·Clifton Gooch, David Podwall
Aug 31, 2006·International Journal of Clinical Practice·G Hackett
May 9, 2001·The Journal of Clinical Investigation·P SchratzbergerJ M Isner
Sep 12, 2015·Journal of Physical Therapy Science·Seung NamkoongJungMyo Shim
Aug 2, 2008·Clinics in Geriatric Medicine·Aaron I VinikChhaya V Patel
Jan 10, 2009·Vascular and Endovascular Surgery·Mark E O'DonnellC V Soong
Feb 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiromi KoikeYasufumi Kaneda

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