Restoring vision

Nature
Botond Roska, José-Alain Sahel

Abstract

Restoring vision to the blind by retinal repair has been a dream of medicine for centuries, and the first successful procedures have recently been performed. Although we are still far from the restoration of high-resolution vision, step-by-step developments are overcoming crucial bottlenecks in therapy development and have enabled the restoration of some visual function in patients with specific blindness-causing diseases. Here, we discuss the current state of vision restoration and the problems related to retinal repair. We describe new model systems and translational technologies, as well as the clinical conditions in which new methods may help to combat blindness.

References

Nov 1, 1991·Experimental Eye Research·J A SahelJ Konrad-Rastegar
Jan 1, 1985·Vision Research·S Remtulla, P E Hallett
Jan 1, 1996·Archives of Ophthalmology·M S HumayunD H Phillips
May 1, 1996·Human Molecular Genetics·R R AliS S Bhattacharya
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·J G FlanneryW W Hauswirth
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Mohand-SaidJ A Sahel
Jun 29, 2004·Nature Genetics·Thierry LéveillardJosé-Alain Sahel
Nov 27, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Barrie J Carter
Nov 10, 2006·Nature·R E MacLarenR R Ali
Nov 23, 2006·Lancet·Dyonne T HartongThaddeus P Dryja
Jul 6, 2007·Experimental Neurology·Larry Benowitz, Yuqin Yin
Apr 29, 2008·The New England Journal of Medicine·Albert M MaguireJean Bennett
Apr 29, 2008·The New England Journal of Medicine·James W B BainbridgeRobin R Ali
Jun 14, 2008·The New England Journal of Medicine·Rama D JagerJoan W Miller
Jul 18, 2008·Progress in Retinal and Eye Research·Anneke I den HollanderFrans P M Cremers
Dec 17, 2008·Nature Neuroscience·André BerndtKarl Deisseroth
Aug 13, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Deniz DalkaraJohn G Flannery
Nov 23, 2010·Current Opinion in Ophthalmology·Ecosse L LamoureuxDonald Tan
Feb 12, 2011·Investigative Ophthalmology & Visual Science·Lu YinWilliam H Merigan
Apr 9, 2011·Nature·Mototsugu EirakuYoshiki Sasai
May 25, 2011·The Journal of Clinical Investigation·Manzar AshtariJean Bennett
Jun 7, 2011·Current Opinion in Neurobiology·Rava Azeredo da Silveira, Botond Roska
Oct 14, 2011·Gene Therapy·V BusskampB Roska
Jan 24, 2012·Nature Neuroscience·Sandra SiegertBotond Roska
Jun 19, 2012·Cell Stem Cell·Tokushige NakanoYoshiki Sasai
Jul 31, 2012·Neuron·J Sebastian Espinosa, Michael P Stryker
Jul 31, 2012·Neuron·Aleksandra PolosukhinaRichard H Kramer
Oct 10, 2012·The Journal of Cell Biology·Iman SahlyChristine Petit
Oct 23, 2012·Neuron·Richard H Masland
Dec 15, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·William SeiplePatricia M T Garcia
Jun 4, 2013·Annual Review of Neuroscience·José-Alain Sahel, Botond Roska
Nov 10, 2013·BMJ Open·Juliane KöberleinRobert P Finger
Dec 7, 2013·Expert Review of Medical Devices·H Christiaan Stronks, Gislin Dagnelie

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Citations

Jan 8, 2020·Journal of Neurogenetics·Nadine Ehmann, Dennis Pauls
Feb 2, 2019·The British Journal of Ophthalmology·Mustafa IftikharSyed Mahmood Ali Shah
Oct 18, 2019·Scientific Reports·Takahiko NoroTakayuki Harada
Jul 3, 2020·Médecine sciences : M/S·Olivier Goureau, Gaël Orieux
Jul 11, 2019·Nature Reviews. Neuroscience·Pierre PaolettiAlexandre Mourot
Jan 8, 2019·International Journal of Radiation Biology·Ruwaidah A MussttafAwadhesh N Jha
Apr 16, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Agustín Luz-MadrigalKatia Del Rio-Tsonis
Jan 31, 2019·International Journal of Molecular Sciences·Thierry Léveillard, Laurence Klipfel
Jun 6, 2020·Science·Katrin Franke, Anna Vlasits
Aug 8, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C CursiefenUNKNOWN das EVI Steering Board
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Serge PicaudJosé-Alain Sahel
Oct 30, 2020·PloS One·Renee C RyalsGaurav Sahay
Jan 9, 2021·Molecular Neurobiology·Hui GaoHaiwei Xu
Nov 15, 2020·The Journal of Biological Chemistry·Philip D Kiser, Krzysztof Palczewski
Sep 23, 2020·Experimental Eye Research·Dominic DidianoJames G Patton
Feb 5, 2021·Frontiers in Cell and Developmental Biology·Gregory J KonarJames G Patton
Aug 5, 2019·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Fatih ZorVijay S Gorantla
Jan 13, 2021·The Journal of Biological Chemistry·Philip D Kiser, Krzysztof Palczewski
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Elizabeth S FishmanAnna La Torre
May 6, 2021·American Journal of Ophthalmology·Etienne M SchönbachUNKNOWN ProgStar Study Group
Apr 4, 2020·Current Biology : CB·Ning ShenDaniel Kerschensteiner
May 26, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Michael B HoffmannRobert J Puzniak
May 18, 2021·American Journal of Ophthalmology·José-Alain SahelKatia Marazova
May 26, 2021·Nature Medicine·José-Alain SahelBotond Roska
Jun 3, 2021·International Journal of Molecular Sciences·Elena MarroccoEnrico Maria Surace
Aug 13, 2021·Frontiers in Neuroscience·Gokulraj T PrabhakaranMichael B Hoffmann
Sep 16, 2021·Annual Review of Vision Science·Joo Yeun LeeFelice A Dunn
Aug 6, 2019·Ophthalmic Research·Claus CursiefenUNKNOWN EVI Steering Board
Dec 15, 2019·Molecular Therapy. Nucleic Acids·Marianthi KaraliSandro Banfi

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Methods Mentioned

BETA
biopsy
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