Restoring vocal fold movement after transection and immediate suturing of the recurrent laryngeal nerve with local application of basic fibroblast growth factor: an experimental study in the rat

The Laryngoscope
Kazumi MotoyoshiKiyofumi Gyo

Abstract

To evaluate the effects of basic fibro-blast growth factor (bFGF) on the recovery of vocal fold movement and the attenuation of laryngeal muscle atrophy after transection of the recurrent laryngeal nerve (RLN). Quantitative assessment of vocal fold movement using the video cassette recorder (VCR) image-analysis method and histologic examination of the laryngeal muscle. Fifty-eight Wistar rats underwent RLN transection and one of the following three procedures: 1) transection of the RLN alone (transection group, n = 18), 2) suture of the nerve stumps followed by local administration of phosphate-buffered saline (PBS) solution using an osmotic pump (PBS group, n =20), or 3) suture of the nerve stumps followed by local administration of bFGF (FGF group, n = 20). Vocal fold movements were recorded with VCR by way of a rigid endoscope, and the VCR images were analyzed on a computer. Histologic changes in the thyroarytenoid (TA) muscle were evaluated by measuring the cross-sectional area of the muscle and average size of muscle fibers. In the transection group, vocal fold movement did not recover, and atrophy of the TA muscle gradually progressed after sectioning the nerve. In contrast, vocal fold movement as assessed by VCR image-an...Continue Reading

References

Jul 1, 1988·Journal of Neuroscience Research·N DanielsenS Varon
Oct 1, 1971·The Annals of Otology, Rhinology, and Laryngology·H H Dedo
Apr 1, 1968·The Annals of Otology, Rhinology, and Laryngology·I IrotoH Tomita
Aug 1, 1969·The Laryngoscope·R Boles, B Fritzell
Jan 1, 1993·American Journal of Otolaryngology·I NahmT Maeyama
Apr 1, 1996·Archives of Otolaryngology--head & Neck Surgery·J P NewmanD J Terris
Feb 27, 2001·The Laryngoscope·A ShiotaniP W Flint

❮ Previous
Next ❯

Citations

Jan 24, 2007·Journal of Voice : Official Journal of the Voice Foundation·Lisa B ThomasJoseph C Stemple
Sep 29, 2006·Journal of Anatomy·Paul J Kingham, Giorgio Terenghi
Feb 8, 2007·The European Journal of Neuroscience·Paul J KinghamMartin A Birchall
Oct 4, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Francesca GattazzoGiovanni Vozzi
Oct 16, 2014·Acta Oto-laryngologica·Kohei NishimotoEiji Yumoto
Apr 18, 2016·European Radiology·Marina Mat BakiShonit Punwani
Feb 2, 2010·The Annals of Otology, Rhinology, and Laryngology·Bryan R McRaeStacey L Halum
Feb 4, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Niv MorRichard Kollmar
Apr 25, 2017·Acta Oto-laryngologica·Takeharu KanazawaYusuke Watanabe
Oct 22, 2018·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·M GazzazH El-Hakim
Mar 6, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Narjes ShahsavaniSoheila Karimi-Abdolrezaee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
J T van Lith-Bijl, H F Mahieu
© 2022 Meta ULC. All rights reserved