Restraint stress affects hippocampal cell proliferation differently in rats and mice

Neuroscience Letters
Megan J BainBenjamin Rusak

Abstract

Granule cell neurogenesis occurs in the dentate gyrus of the mammalian hippocampus throughout adult life, and incorporation of bromodeoxyuridine (BrdU) into DNA can serve as a marker of cell division associated with such neurogenesis. We examined the effects of a stressor (3h of restraint) on hippocampal cell proliferation in Sprague-Dawley rats and C57BL/6J mice. Animals were killed immediately following restraint stress and their brains were prepared for immunohistochemical studies. Restraint stress caused similar significant increases in c-Fos immunoreactivity among cells in the hypothalamic paraventricular nucleus of both species, indicating that the stress experienced was similar. The restraint procedure also caused a significant decrease in BrdU labeling in the dentate gyrus of rats, as previously reported, but a significant increase in the same region in mice. Hippocampal cell proliferation appears to respond differently to restraint stress in these species.

References

Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Apr 5, 2002·Journal of Neuroscience Research·Mariko YamanoHiroko Ohki-Hamazaki

❮ Previous
Next ❯

Citations

Jan 19, 2010·Chinese Journal of Integrative Medicine·Shi-feng Chu, Jun-tian Zhang
Jul 7, 2009·Annual Review of Psychology·Benedetta Leuner, Elizabeth Gould
Jan 5, 2008·Journal of Neurosurgery·Hiroki TodaAndres M Lozano
Aug 2, 2011·Behavioural Brain Research·Woon Ryoung KimHongjun Song
Mar 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Wook LimDaeseok Han
Jun 5, 2007·Frontiers in Neuroendocrinology·Marian JoëlsPaul J Lucassen
Jan 16, 2007·Progress in Neurobiology·Benjamin W Lindsey, Vincent Tropepe
Oct 17, 2006·The European Journal of Neuroscience·Katsunori KobayashiHidenori Suzuki
Jul 15, 2006·Behavioural Brain Research·Jasmine J YapBarry L Jacobs
Aug 9, 2006·Biological Psychiatry·Diane C LagaceAmelia J Eisch
Sep 9, 2015·The International Journal of Neuropsychopharmacology·Chien-Chung ChenKuei-Sen Hsu
Oct 5, 2010·Neuroscience and Biobehavioral Reviews·Karen Wager-Smith, Athina Markou
Feb 18, 2015·Behavioural Brain Research·Yuki OtaToshio Matsuda
Feb 2, 2011·Experimental Neurology·Timothy J Schoenfeld, Elizabeth Gould
May 2, 2014·Frontiers in Behavioral Neuroscience·Annemarie ZimprichSabine M Hölter
Nov 5, 2016·Neuroscience·Catherine LauJacqueline Blundell
Jul 6, 2007·Expert Review of Neurotherapeutics·Vidita A VaidyaShanker Jha
Jan 16, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L SchipperG van Dijk
Jan 18, 2006·Hippocampus·Christian Mirescu, Elizabeth Gould

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.