Restraint stress exacerbates cardiac and adipose tissue pathology via β-adrenergic signaling in rats with metabolic syndrome

American Journal of Physiology. Heart and Circulatory Physiology
Natsumi MatsuuraKohzo Nagata

Abstract

Restraint stress stimulates sympathetic nerve activity and can affect adiposity and metabolism. However, the effects of restraint stress on cardiovascular and metabolic disorders in metabolic syndrome (MetS) have remained unclear. We investigated the effects of chronic restraint stress and β-adrenergic receptor (β-AR) blockade on cardiac and adipose tissue pathology and metabolic disorders in a rat model of MetS. DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats. Rats were exposed to restraint stress (restraint cage, 2 h/day) for 4 wk from 9 wk of age with or without daily subcutaneous administration of the β-AR blocker propranolol (2 mg/kg). Age-matched homozygous lean littermates of DS/obese rats (DahlS.Z-Lepr(+)/Lepr(+) rats) served as control animals. Chronic restraint stress exacerbated hypertension as well as left ventricular hypertrophy, fibrosis, diastolic dysfunction, and oxidative stress in a manner sensitive to propranolol treatment. Restraint stress attenuated body weight gain in DS/obese rats, and this effect tended to be reversed by propranolol (P = 0.0682). Restraint stress or propranolol did not affect visceral or subcutaneous fat mass. However, restraint...Continue Reading

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Citations

Apr 4, 2017·Journal of Molecular and Cellular Cardiology·John P HeadrickNicolas J C Stapelberg
Jul 5, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Yu QiaoXiaojing Yang
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Oct 4, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Yusuke SanoKohzo Nagata
Jan 27, 2019·International Journal of Experimental Pathology·Shogo WatanabeSatoshi Hirohata
Dec 20, 2020·Annals of the New York Academy of Sciences·Yuki KomatsuKohzo Nagata
Jul 7, 2020·Molecular and Cellular Neurosciences·Michael A van der Kooij

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