Restraint stress induced changes in rat liver and serum metallothionein and in Zn metabolism

Experientia
J HidalgoJ S Garvey

Abstract

24 h of a psychogenic stress (restraint) caused a strong increase of liver metallothionein (MT) levels. 3 h of stress were sufficient to induce an increase in liver MT, measured 21 h later, but the increase was much lower than in continuously restrained rats. Stress induction of liver MT was not due to food deprivation, since rats deprived for 24 h showed lower MT levels than stressed ones. Zn on MT presented the same qualitative but not quantitative pattern of response as MT protein. Liver cytosolic Zn was increased by restraint in spite of their being no decrease in serum Zn. Any treatment altered serum MT. Liver and serum MT were not correlated. The present results demonstrate that basically psychogenic stresses increased liver but not serum MT levels. No positive evidence for a relationship between corticosterone secretion and MT induction was found.

References

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Citations

Feb 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D N WeberD H Petering
Jun 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·E Canpolat, M A Lynes
Dec 1, 1989·Environmental Research·B A HartJ S Garvey
Mar 9, 2007·Biochemical Pharmacology·Barbara L Vogt, John P Richie
Oct 1, 1988·The American Journal of Physiology·J HidalgoA Armario

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