Restraint stress-induced thymic involution and cell apoptosis are dependent on endogenous glucocorticoids

Journal of Neuroimmunology
Nora TarcicJoseph Weidenfeld

Abstract

The aim of this study was to investigate the specific role of endogenous glucocorticoids (GC) following restraint stress on thymic involution and apoptosis. Restraint stress has been reported to alter physiological and behavioral responses in experimental animals. Exposure of mice to restraint stress led to involution of the thymus, to a decrease of the CD4+ 8+ thymocyte subset, and to fragmentation of thymic DNA. The role of endogenous GC in restraint stress-induced changes in the thymus was studied by three experimental approaches: surgical adrenalectomy, chemical adrenalectomy, and blocking of GC receptors by a specific type II receptor antagonist. In surgically-Adx mice, which lack endogenous GC, the effects of restraint on the thymus were wholly abrogated. Pretreatment of restrained mice with metyrapone (an 11beta hydroxylase inhibitor that specifically inhibits GC biosynthesis) had the same consequence, and blockage of GC receptors with the specific GC type II receptor antagonist RU-38486 attenuated the effects of the stressor. These findings indicate that GC are involved in the restraint-induced effects on the thymus.

Associated Clinical Trials

Nov 2, 2006·Michael Dean, Michael Dean

References

Dec 1, 1992·Biochemical Pharmacology·X M SunD N Skilleter
Apr 15, 1992·Annals of the New York Academy of Sciences·H TeshimaT Nakagawa
Aug 1, 1992·Cellular Immunology·S J Leu, V K Singh
Sep 1, 1991·Endocrinology·J J McGloneR L Norman
Sep 1, 1991·Journal of Neuroimmunology·S J Leu, V K Singh
Jan 1, 1991·Life Sciences·H TeshimaT Nakagawa
Nov 1, 1990·Journal of Neuroimmunology·K NakamuraK Kawai
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·R AderN Cohen
Oct 1, 1990·General and Comparative Endocrinology·M M ComptonL R Swicegood
May 1, 1990·The Journal of Experimental Medicine·W HeagyR Finberg
Feb 1, 1989·Immunology Today·H von BoehmerP Kisielow
Oct 1, 1989·The Journal of Investigative Dermatology·L A RheinsJ J Nordlund
Jun 1, 1989·International Reviews of Immunology·D J Carr, J E Blalock
Dec 1, 1987·Immunological Reviews·D A Weigent, J E Blalock
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·W P Paré, G B Glavin
Mar 1, 1987·Brain, Behavior, and Immunity·M R IrwinK T Britton
Jan 1, 1982·Immunological Reviews·T R Cupps, A S Fauci
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H M JohnsonJ E Blalock
Nov 1, 1994·Neuroimmunomodulation·S Tsagarakis, A Grossman
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·G B GlavinR Murison
Oct 21, 1993·The New England Journal of Medicine·S Reichlin
May 1, 1994·European Journal of Immunology·J GruberG Wick
Sep 1, 1993·The American Journal of Physiology·J P Concordet, A Ferry
Apr 1, 1993·Journal of Neuroimmunology·A C GriffinC C Whitacre
Feb 1, 1996·Endocrine Reviews·H O Besedovsky, A del Rey

❮ Previous
Next ❯

Citations

Oct 13, 2006·European Journal of Applied Physiology·Ken ShiratoKazuhiko Imaizumi
Aug 6, 2000·Cell and Tissue Research·R D Medh, E B Thompson
Aug 3, 2005·Brain, Behavior, and Immunity·Joe Quadrilatero, Laurie Hoffman-Goetz
Mar 31, 2004·Experimental Gerontology·Sian M HensonRichard Aspinall
Dec 9, 2000·Physiology & Behavior·L Hoffman-GoetzG Ward
Jun 5, 2002·Mechanisms of Ageing and Development·Hui-Chen HsuGary Van Zant
May 14, 2003·Journal of Neuroimmunology·Volker StefanskiStefan Reber
Mar 4, 2000·Applied Animal Behaviour Science·J C ColletteP S Wakenell
Nov 25, 2000·International Journal of Immunopharmacology·T HasegawaY Yoshikai
May 24, 2003·Experimental Hematology·Marie-Eve BlaisClaude Perreault
Oct 8, 2003·Psychoneuroendocrinology·Harald Engler, Volker Stefanski
Jun 8, 2000·Forensic Science International : Synergy·H NishioK Suzuki
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Stephen B. Pruett
May 23, 2001·International Immunopharmacology·S B Pruett
Jun 28, 2003·Viral Immunology·Michael BaileyJohn F Sheridan
May 23, 2008·Journal of Leukocyte Biology·Amanda L Gruver, Gregory D Sempowski
Jan 18, 2014·Brain, Behavior, and Immunity·Adria Prieto-HinojosaPaul J Travers
Aug 3, 2014·The Journal of Pediatrics·Helle Brander EriksenChristine Stabell Benn
Jun 13, 2014·Genes and Immunity·J SarmientoP Poussier
Feb 13, 2016·Frontiers in Endocrinology·Andrea Rodrigues VasconcelosElisa Mitiko Kawamoto
Jan 29, 2016·American Journal of Obstetrics and Gynecology·Salvatore Andrea MastroliaReli Hershkovitz
May 17, 2011·Journal of Neuropathology and Experimental Neurology·Elisabet DachsJosep E Esquerda
Aug 17, 2005·Scandinavian Journal of Immunology·H NishioK Suzuki
Apr 21, 2007·Scandinavian Journal of Immunology·M Fritsch FredinE Hultgren Hörnquist
May 12, 2011·British Journal of Pharmacology·E Y ZhangT M Yankee
Oct 19, 2004·Trends in Immunology·Mikael JondalSam Okret
May 20, 2003·Scandinavian Journal of Immunology·L LiG E William
May 11, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B BiolattiG Barbarino
Apr 23, 2015·Applied Biochemistry and Biotechnology·Nidhi RajuChandrasekaran Guruvayoorappan
Jun 3, 2000·Annual Review of Immunology·J D AshwellM S Vacchio
Mar 15, 2015·Legal Medicine·Shuntaro AbeKlaus Püschel
May 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara L F KaplanPeer W F Karmaus
Oct 21, 2009·Neuron·Shawn F SorrellsRobert M Sapolsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis