PMID: 7019375Apr 1, 1981Paper

Restricted antibody formation to sheep erythrocytes of allogeneic bone marrow chimeras histoincompatible at the K end of the H-2 complex

The Journal of Experimental Medicine
K OnoeK Morikawa

Abstract

Employing a new method for allogeneic bone marrow transplantation, irradiation chimeras constructed from various combinations of marrow cells from B10 H-2 recombinant mice and AKR recipients were prepared. Though these chimeras had well-developed populations of T and B cells, they showed strikingly different patterns of responses in the primary antibody formation to sheep erythrocytes (SRBC), a T dependent antigen. These are (a) AKR mice treated with C57BL/10 cells, [B10 leads to AKR] fully H-2 incompatible, and AKR mice treated with B10.A (5R) cells, [5R leads to AKR] I-J,E compatible chimeras that were almost completely unresponsive to SRBC; (b) AKR mice treated with B10.BR cells [BR leads to AKR] fully H-2 compatible, and AKR mice treated with B10 AKM cells, [AKM leads to AKR] chimeras where donor and recipient differed only at H-2D, showed the same number of plaque-forming cells (PFC) as B10 control mice; (c) AKR mice treated with B10.A cells, [B10 leads to AKR] chimeras, where donor and recipient were matched at H-2K-I-E region, showed about one-half the number of PFC as the control mice. From these results we conclude that in allogeneic bone marrow chimeras primary antibody response to T-dependent antigen, such as SRBC, i...Continue Reading

References

Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G FernandesR A Good
Jan 1, 1980·The Journal of Experimental Medicine·F I Smith, J F Miller
Jan 1, 1980·The Journal of Experimental Medicine·K OnoéR A Good

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Citations

Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M NoguchiK Morikawa
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Himeno, R A Good
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K IwabuchiK Onoé
Feb 1, 1987·European Journal of Immunology·H PircherR M Zinkernagel
May 1, 1990·European Journal of Immunology·N FukushiK Onoé
Dec 29, 1995·Annals of the New York Academy of Sciences·R A Good

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