Restricted diffusion and release of aroma molecules from sol-gel-made porous silica particles

Journal of Controlled Release : Official Journal of the Controlled Release Society
Susanne R VeithSotiris E Pratsinis

Abstract

The aim of the current study is to predict the release kinetics of organic molecules entrapped in sol-gel-made silica particles using both pulsed field gradient-nuclear magnetic resonance (PFG-NMR) techniques and model calculations to describe restricted diffusion. The macroscopic release profile of aroma molecules from sol-gel-made particles is measured directly by UV-VIS spectroscopy, while the release kinetics are calculated by the Crank equation. The microscopic restricted pore diffusion coefficient of the aroma molecules in the Crank equation is obtained in situ by pulsed field gradient (PFG) magic angle spinning (MAS) nuclear magnetic resonance (NMR). Furthermore, restricted pore diffusion coefficients obtained by model calculations are in agreement with those measured by PFG-MAS-NMR, indicating the potential of the latter for characterization and screening of encapsulation formulations. Measured and calculated release profiles agree within experimental error.

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Citations

Oct 2, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elena V Parfenyuk, Ekaterina S Dolinina
May 10, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fengbin YeJesper Østergaard
Mar 19, 2016·Magnetic Resonance in Chemistry : MRC·Ana S D FerreiraEurico J Cabrita
Sep 12, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yusuke NagaiShuguang Zhang
Sep 26, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Songmiao LiangLina Zhang
May 29, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·María Ruiz-RicoJosé M Barat
Feb 1, 2017·Pharmaceutical Research·Elena V Parfenyuk, Ekaterina S Dolinina
Mar 28, 2018·Pharmaceutical Development and Technology·Mariya I VlasenkovaElena V Parfenyuk
Jul 16, 2008·Soft Matter·Job UbbinkRaffaele Mezzenga
Mar 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tadeusz Kosztołowicz
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tadeusz KosztołowiczKatarzyna D Lewandowska
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zuobing XiaoXingran Kou
Jun 20, 2020·Analytical Chemistry·Mateusz UrbańczykVille-Veikko Telkki

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