Restricted Effect of Cerebral Microbleeds on Regional Magnetic Susceptibility.

Journal of Alzheimer's Disease : JAD
Amir FazlollahiScott Ayton

Abstract

Cortical iron accumulation has been reported as a pathological feature of Alzheimer's disease (AD). The cause of cortical iron elevation in AD is unknown but may be contributed by hemosiderin deposits in cerebral microbleeds that frequently occur in this disease. To investigate the impact of cerebral microbleeds (which are more frequent in AD) on the magnetic susceptibility of the surrounding brain tissue. 32 MRI scans from the Australian Imaging, Biomarker and Lifestyle (AIBL) study were found to have cerebral microbleeds by manual assessment of susceptibility weighted images. Quantitative susceptibility mapping (QSM; an MRI technique that is sensitive to iron) was used to estimate iron content in the tissue surrounding the microbleed in four concentric radii. Furthermore, the mirror regions on the contralateral hemisphere were also demarcated. A simulation analysis was conducted to investigate the effect of QSM imaging on cerebral microbleeds with varying sizes. 77 microbleeds were identified from the available scans. The immediate proximal region to the cerebral microbleeds had enhanced tissue susceptibility (∼0.02 PPM), but importantly, this did not extend beyond one voxel radius. This finding with in vivo data was also rep...Continue Reading

References

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Citations

Jan 26, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Scott AytonAshley I Bush
Oct 27, 2020·Journal of Alzheimer's Disease : JAD·Mana ShamsSara Shams
Jan 24, 2021·NeuroImage·Negin YaghmaieLeigh A Johnston
Feb 17, 2021·Current Opinion in Neurology·Rupal I Mehta, Julie A Schneider

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