Restricted expression of Fc gammaRIII (CD16) in synovium and dermis: implications for tissue targeting in rheumatoid arthritis (RA)

Clinical and Experimental Immunology
J C EdwardsG Cambridge

Abstract

Interactions between immune complexes and immunoglobulin Fc receptors may contribute to inflammation in RA. Previous studies suggested that Fc gammaRIII (CD16) may be preferentially expressed in diseased synovial intima. The distribution of immunoreactive Fc gammaRIII was examined in normal fetal limb tissues, and both normal and selected abnormal samples of adult synovium and skin. In fetal limbs at 10-14 weeks gestation Fc gammaRIII was restricted to synovial intima. In normal adult synovium Fc gammaRIII was restricted to intimal cells. In inflamed synovia differential expression of Fc gammaRIII in the intima was less consistent. In both fetal and adult synovium Fc gammaRIII was largely restricted to cells expressing CD45 (leucocyte common antigen). Staining for Fc gammaRIII was, however, occasionally associated with CD45 intimal cells in fetal synovium. In both fetal and adult tissues cell membrane Fc gammaRIII was frequently closely associated with complement decay-accelerating factor (DAF), which is present on intimal fibroblasts and extracellular matrix. Fc gammaRIII expression was minimal in normal forearm dermis, but widespread on CD45+ cells in skin exposed to mechanical stress. In skin containing rheumatoid nodules, F...Continue Reading

Citations

May 25, 2007·Arthritis Research & Therapy·Sofia E MagnussonSandra Kleinau
Mar 25, 2008·Therapeutics and Clinical Risk Management·Adam Bryant, John Moore
Jun 10, 2000·The British Journal of Dermatology·R C KiekensC A Bruijnzeel-Koomen
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Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maripat Corr, Brian Crain

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