Restricted lesions of the ventrolateral or dorsal columns of the periaqueductal gray promotes distinct effects on tonic immobility and defensive analgesia in guinea pigs

Physiology & Behavior
Eveline Bis Vieira-RasteliChristie Ramos Andrade Leite-Panissi

Abstract

Tonic immobility (TI) is an innate defensive response exhibited by prey when physical contact with a predator is prolonged and inescapable. This defensive response is able to activate analgesia mechanisms; this activation has adaptive value because, during an attack by a predator, the manifestation of recuperative behaviors can affect the appropriate behavioral defense strategy. Some studies have suggested that similar structures of the central nervous system can regulate the response of both TI and nociception. Thus, this study evaluated the effect of chemical lesion through the administration of ibotenic acid in restricted brain areas of the periaqueductal gray matter (PAG) in guinea pig on the TI response and nociception evaluated in the hot plate test before and after emission of TI. The data showed that an irreversible chemical lesion in the ventrolateral PAG reduced of the TI response as well as defensive antinociception. However, a lesion in the dorsal PAG blocked the defensive antinociception induced by TI but did not alter TI duration. In summary, one could hypothesize that the neural substrates responsible for defensive behavior and antinociception represent similar systems that are distinct in modulation. Thus, the v...Continue Reading

References

May 11, 1979·Brain Research·U Jürgens, R Pratt
Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J B SchulzK Zilles
Jan 1, 1988·Annual Review of Psychology·D C Blanchard, R J Blanchard
Jan 1, 1984·Annual Review of Neuroscience·A I Basbaum, H L Fields
Jan 14, 1995·Brain Research. Developmental Brain Research·F C ZhouS Bledsoe
Sep 30, 1993·Behavioural Brain Research·L Menescal-de-Oliveira, A Hoffmann
Feb 1, 1996·Trends in Neurosciences·P S Katz, W N Frost
Dec 14, 1999·Neuroscience and Biobehavioral Reviews·M L BrandãoV M Castilho
Nov 24, 1999·Brain Research Bulletin·C R MonassiL Menescal-de-Oliveira
Feb 15, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R Leite-PanissiL Menescal-De-Oliveira
Sep 5, 2002·Respiratory Physiology & Neurobiology·Luciane H GargaglioniL G S Branco
Sep 28, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R A Leite-PanissiL Menescal-de-Oliveira
Apr 21, 2006·Brain Research Bulletin·Christie Ramos Andrade Leite-PanissiLeda Menescal-de-Oliveira
Oct 13, 2009·Biological Psychiatry·Clement HamaniJosé N Nobrega
Jul 27, 2010·Behavioural Brain Research·Eveline Bis VieiraChristie Ramos Andrade Leite-Panissi
Jan 19, 2016·Pharmacology, Biochemistry, and Behavior·Abraham Miranda-PáezEduardo Ramírez-San Juan

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Citations

Jun 30, 2019·Journal of Neuroscience Research·Braeden A TerpouRuth A Lanius
May 28, 2019·Frontiers in Behavioral Neuroscience·Tamara B Franklin

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