PMID: 6979607Jul 1, 1982Paper

Restricted nucleocytoplasmic relationship in activation of T and B lymphocytes

The Journal of Experimental Medicine
T WatanabeJ Ohara

Abstract

Nuclei of murine T lymphocytes or B lymphocytes were purified and transferred into lethally irradiated whole spleen cells or B or T lymphocytes by means of polyethyleneglycol-mediated cell fusion. Transfer of lymphocyte nuclei could save the irradiated cells from cell death, and such reconstituted cells could respond to mitogens. The present study showed that nuclei of T cells could be activated in the concanavalin A-stimulated T cell cytoplasms but not in the lipopolysaccharide-stimulated B cell cytoplasms. On the other hand, nuclei of B cells were activated in the lipopolysaccharide-stimulated B cells but not in the concanavalin A-stimulated T cell cytoplasms. These data suggested that a specific interaction between cytoplasm and nucleus might exist in the activation of nuclei of each lymphocyte subset.

References

Jan 1, 1975·Somatic Cell Genetics·T EgeN R Ringertz
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D C Burke, G Veomett
Apr 7, 1975·Biochemical and Biophysical Research Communications·M H Wigler, I B Weinstein
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·G VeomettK R Porter
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J W Shay, M A Clark
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S LinderN R Ringertz

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