Restricted pulmonary diffusion capacity after exercise is not an ARDS-like injury

Journal of Sports Sciences
H B NielsenN H Secher

Abstract

Pulmonary diffusion capacity (DLCO) is reduced 2 h after various types of exercise, such as rowing, treadmill running, arm cranking and marathon running. The decrease in DLCO may involve alterations in the alveolar-capillary membrane as well as depletion of the central blood volume. We hypothesized that the reduction in DLCO might also be influenced by oxygen free radicals, acute phase proteins and endotoxin, which are also involved in the adult respiratory distress syndrome (ARDS). Ten competitive male oarsmen performed a 6 min 'all-out' ergometer row. Single breath DLCO was determined before and 2 h after rowing and venous blood samples were also obtained during the row. Absolute DLCO decreased by 11% (range 0-20%) 2 h after rowing, whereas the concentration of endotoxin did not change significantly and interleukin (IL)-1-alpha, IL-8 and tumour necrosis factor (TNF)-alpha were below the levels of detection before, during and 2 h after rowing. Oxygen free radicals were evaluated by oxidative modification of amino acids and DNA. Corrected for creatinine in urine voided 3 h post-exercise, the DNA repair product 8-oxo-7,8-dehydro-2-deoxyguanosine (8-oxodG) did not change significantly. The ratio of fluorescence due to dityrosine ...Continue Reading

References

Jan 1, 1992·Free Radical Research Communications·B Halliwell, M Dizdaroglu
Dec 1, 1992·Journal of Sports Sciences·J RasmussenN H Secher
May 1, 1992·Journal of Applied Physiology·W SchaffartzikP D Wagner
May 1, 1992·Journal of Applied Physiology·M L Barnard, S Matalon
Jan 1, 1991·European Journal of Drug Metabolism and Pharmacokinetics·H Lew, A Quintanilha
Feb 1, 1991·Respiration Physiology·G ManierH Guénard
Mar 1, 1990·World Journal of Surgery·C Runcie, G Ramsay
Oct 1, 1990·Sports Medicine·B SjödinF S Apple
Apr 1, 1989·The Journal of Surgical Research·M A GrossoA H Harken
Aug 1, 1989·The American Review of Respiratory Disease·P E ParsonsP M Henson
Jan 1, 1988·Journal of Sports Sciences·B S RasmussenB Juhl
Jul 1, 1988·Journal of Applied Physiology·A T BosenbergG T Blake
Jan 1, 1986·Journal of Sports Sciences·B S RasmussenN H Secher
Jun 1, 1983·Respiration Physiology·D S MilesR W Gotshall
Aug 1, 1993·Journal of Applied Physiology·C A ViguieG A Brooks
Oct 1, 1993·Medicine and Science in Sports and Exercise·D CriswellS Grinton
Sep 1, 1993·International Journal of Sports Medicine·B HanelN H Secher
May 12, 1915·The Journal of Physiology·M Krogh

❮ Previous
Next ❯

Citations

Dec 1, 2001·Free Radical Biology & Medicine·K TsaiC W Kong
Aug 1, 1996·Journal of Sports Sciences·H E PoulsenK Vistisen
Aug 30, 2006·The American Journal of Emergency Medicine·Leon D SanchezDavid Berkoff
Sep 6, 2005·Clinics in Chest Medicine·Susan R Hopkins
Mar 3, 2001·Sports Medicine·A I MoldoveanuP N Shek
Sep 10, 2003·Sports Medicine·Henning Bay Nielsen
Nov 18, 2003·Scandinavian Journal of Medicine & Science in Sports·Henning Bay Nielsen
May 19, 2000·The Proceedings of the Nutrition Society·H E PoulsenS Loft
Jul 1, 1997·Journal of Applied Physiology·B HanelN H Secher
Dec 13, 2005·Sports Medicine·Niels B J VollaardChris E Cooper
Aug 29, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·M AbdelrahimA Verma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Sports Medicine
S Brosh, J R Jenner
European Journal of Applied Physiology and Occupational Physiology
R L Jensen, F I Katch
European Journal of Applied Physiology and Occupational Physiology
R StupnickiA Viru
© 2021 Meta ULC. All rights reserved