Restricted replication of Listeria monocytogenes in a gamma interferon-activated murine hepatocyte line.

Infection and Immunity
G SzalayS H Kaufmann

Abstract

The intracellular pathogen Listeria monocytogenes replicates mainly in resting macrophages and hepatocytes residing in infected tissues. Both innate and acquired resistance strongly depend on activation of listericidal capacities of macrophages by gamma interferon (IFN-gamma) produced by natural killer cells and T lymphocytes. In contrast to macrophages, hepatocytes have been considered to serve purely as a cellular habitat, prolonging survival of the pathogen in the host. By using an immortalized murine hepatocyte line, the relationship between L. monocytogenes and this cell type has been analyzed in more detail. Our data reveal that hepatocytes are able to eradicate listeriolysin-deficient (avirulent) L. monocytogenes but fail to control growth of listeriolysin-expressing (virulent) L. monocytogenes organisms. Following stimulation with IFN-gamma, hepatocytes gained the capacity to restrict growth of virulent L. monocytogenes, although less efficiently than the highly listericidal IFN-gamma-activated macrophages. Hepatocytes costimulated with a combination of IFN-gamma, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) expressed the highest antilisterial activities. Although IFN-gamma-stimulated hepatocytes pr...Continue Reading

References

Apr 1, 1992·Infection and Immunity·D A PortnoyP Cossart
Aug 11, 1991·The Journal of Experimental Medicine·C E AlfordP A Campbell
Nov 1, 1989·The Journal of Experimental Medicine·R D CurranR L Simmons
Dec 1, 1989·The Journal of Experimental Medicine·D A PortnoyL G Tilney
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R IyengarM A Marletta
Feb 1, 1987·European Journal of Immunology·S H KaufmannG De Libero
Sep 1, 1987·Infection and Immunity·C J Czuprynski, J F Brown
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A Buchmeier, R D Schreiber
Oct 1, 1984·European Journal of Immunology·A F KiderlenM L Lohmann-Matthes
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar
Jun 1, 1994·Infection and Immunity·D A DrevetsP A Campbell
Aug 1, 1993·Current Opinion in Immunology·G J Bancroft
Aug 1, 1993·Current Opinion in Immunology·S L James, C Nacy
Jan 1, 1993·Annual Review of Immunology·S H Kaufmann
Jul 1, 1993·Infection and Immunity·S WoodC J Czuprynski
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS

❮ Previous
Next ❯

Citations

Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sascha MartensJonathan C Howard
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S BregenholtJ P Di Santo
Jul 4, 2001·Clinical Microbiology Reviews·J A Vázquez-BolandJ Kreft
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas RansonJames P Di Santo
Jan 25, 2018·Pathogens·Michelle G Pitts, Sarah E F D'Orazio
Oct 25, 1996·Annals of the New York Academy of Sciences·U S BabuR B Raybourne
Aug 26, 1998·Infection and Immunity·E R JensenS H Gregory

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.