PMID: 2492697Feb 1, 1989Paper

Restriction of HIV-1 replication in promonocytic cells: a role for IFN-alpha

Virology
K MacéL Gazzolo

Abstract

A comparative study of the replication kinetics of human immunodeficiency virus type 1 (HIV-1) was performed in the promonocytic U937 cells and in the T lymphoblastoid H9 cells. If a productive HIV-1 infection of both cell types could be established, the time which elapses before most of the cells could express viral proteins is always proportionally longer for U937 cells than for H9 cells. Indeed, when U937 cells are infected with HIV-1, this nonproductive phase is followed by a lag phase during which the percentage of virus-producing cells is slowly increasing when compared to H9 cells. The restriction of HIV-1 replication in U937 cells might be consecutive to the lower adsorption of viral particles to these cells, even though the same percentage of U937 and H9 cells was expressing the CD4 molecule. Furthermore, we demonstrate that HIV-1 replication in U937 cells is mainly restricted by endogenous IFN-alpha. Indeed, addition of anti-IFN-alpha antibodies at the time of infection, during the nonproductive phase of the viral replication cycle, or during the lag phase leads to an earlier expression of viral proteins and/or to a rapid increase in the percentage of virus-producing cells. Likewise, the treatment of cultures of HIV-1...Continue Reading

References

May 15, 1976·International Journal of Cancer. Journal International Du Cancer·C Sundström, K Nilsson
May 1, 1986·The Journal of Clinical Investigation·D D HoM S Hirsch
Mar 1, 1985·The Biochemical Journal·M J Clemens, M A McNurlan
Oct 17, 1987·Lancet·M Popovic, S Gartner
Nov 7, 1986·JAMA : the Journal of the American Medical Association·K J ChaytR C Gallo

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Citations

Dec 29, 2011·Current Infectious Disease Reports·Basile Siewe, Alan Landay
Jan 1, 1995·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I V ChernukhinK V Gaidul
Mar 1, 1990·Research in Virology·L Gazzolo, K Macé
Dec 29, 1998·Biochimie·F DianzaniM R Capobianchi
Dec 1, 1991·Journal of Interferon Research·P M Pitha
Dec 21, 2012·Journal of Virology·Stéphanie CordeilAndrea Cimarelli
Nov 1, 1990·Microbial Pathogenesis·L WuK Leary
Feb 1, 1990·Clinical Immunology and Immunopathology·R S KornbluthD D Richman
Oct 1, 1994·Research in Immunology·E LauretE De Maeyer
Oct 1, 1994·Research in Immunology·H E GendelmanS Skurkovich
Nov 1, 1991·Cytokine·W L FarrarK A Clouse
Apr 21, 2017·Journal of Virology·Caitlin M MillerSuryaram Gummuluru
Aug 31, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Taha HirbodKristina Broliden
Sep 6, 2018·The Journal of Biological Chemistry·Sarah A MerebyBaek Kim

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