PMID: 6107035May 1, 1980Paper

Restriction of latent herpes virus infection in rabbits immunized with subviral herpes simplex virus vaccine

Acta Virologica
J RajcániV Vonka

Abstract

The ability of an experimental herpes simplex virus type 1 (HSV) vaccine to influence the establishment of latent infection was examined. The virion-free vaccine was prepared from HSV 1-infected LEP cells by extraction with Nonidet P 40. Albino rabbits were immunized with three doses of the subviral vaccine (strain KOS) and challenged with 10(5) PFU of HSV 1 (Kupka strain) into the right scarified cornea. Non-immune controls and rabbits immunized with formalin-inactivated virion vaccine (strain KOS) were infected in a similar way. At intervals from 53 to 164 days p. i., the animals were killed and fragments of both trigeminal ganglia were kept separately in culture for 10 days. In 18 out of 22 immunized animals (81.8%), latency was established in the homolateral Gasserian ganglion. The proportion of HSV-yielding fragments, was considerably higher in ganglia from non-immune animals (42.6%) as compared to those from ganglia of rabbits immunized with the subviral vaccine (5.4%) or with the whole virion vaccine (14.6%). The immunity resulting from previous vaccination restricted about 5 times the number of ganglion cells, which become virus carriers.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.