PMID: 6965398Feb 1, 1980Paper

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts

The Journal of Experimental Medicine
R M ZinkernagelP Pincetl

Abstract

Congenitally thymusless nude mice that lacked functional T cells were reconstituted with H-2-compatible or -incompatible thymus grafts taken from either fetal, newborn, or adult mice and transplanted under the kidney capsule or subcutaneously. Transplantation with unirradiated fetal (15--17 d) or newborn thymus grafts reconstituted the nude mice as assessed by their subsequent generation of virus-specific cytotoxic T cells in vivo or alloreactive T cells in vitro. The restriction specificity of T cells from homozygous mice was exclusively for the nude host H-2, as shown by direct cytolysis or by cold target competitive inhibition assays. irrespective of whether nude mice were reconstituted with H-2-compatible, semiallogeneic, or H-2-incompatible, unirradiated newborn or fetal thymus grafts (in order of decreasing efficiency of reconstitution). The restriction specificity for the nonhost H-2 of the thymus could not be demonstrated even after primary or secondary sensitization in an infected appropriate F1 environment. These nude mice reconstituted with fetal or newborn grafts were tolerant to the H-2 of the thymus donors. Nude mice transplanted with irradiated adult thymus grafts were reconstituted functionally with syngeneic or...Continue Reading

References

Oct 1, 1976·European Journal of Immunology·U Koszinowski, H Ertl
Jan 1, 1979·Scandinavian Journal of Immunology·J F MillerF I Smith
Jun 1, 1979·The Journal of Experimental Medicine·S GillisK A Smith
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Sep 19, 1979·The Journal of Experimental Medicine·R M ZinkernagelG Callahan
Jan 1, 1977·Immunological Reviews·K J Lafferty, J Woolnough
Jul 1, 1977·Developmental and Comparative Immunology·B Kindred
Apr 1, 1976·The Journal of Experimental Medicine·K PfizenmaierH Wagner
Mar 1, 1974·Journal of Immunological Methods·K LaffertyI Misko
Jan 1, 1969·Pathologia et microbiologia·H Ramseier, J Lindenmann
Jun 1, 1972·European Journal of Immunology·B W ChesebroT G Wegmann
Jan 1, 1969·Transplantation Reviews·A J Davies
Jan 1, 1971·European Journal of Immunology·N K Jerne

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Citations

Jan 1, 1981·Journal of Immunological Methods·J R Bennink, P C Doherty
Dec 1, 1988·Immunology Today·P J Fink
May 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·I KhazaalN Le Douarin
May 24, 2003·Experimental Hematology·Marie-Eve BlaisClaude Perreault
May 21, 2008·Nature Immunology·Harald von Boehmer
Apr 2, 2004·Nature Reviews. Immunology·C Clare Blackburn, Nancy R Manley
Oct 3, 2002·British Journal of Haematology·Jean-François LambertPeter J Quesenberry
Oct 16, 1999·The New England Journal of Medicine·M L MarkertB F Haynes
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J Fink, M J Bevan
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S IkeharaR A Good
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J S MarkowitzL H Glimcher
Jun 1, 1981·The Journal of Experimental Medicine·A N Barclay, G Mayrhofer
Sep 1, 1982·The Journal of Experimental Medicine·V DuprezS J Burakoff
Dec 1, 1984·The Journal of Experimental Medicine·F P GuillemotN M Le Douarin
Dec 1, 1988·The Journal of Experimental Medicine·M G RoncaroloH Spits
Jul 31, 2004·Immunology and Cell Biology·Rolf M Zinkernagel
Dec 27, 1990·European Journal of Biochemistry·H von Boehmer
Oct 1, 1993·Immunological Reviews·H von BoehmerP Kisielow
Oct 1, 1993·Immunological Reviews·J I Elliott
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marianne M MartinicRolf M Zinkernagel
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·R M Zinkernagel, A Althage
Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marianne M MartinicRolf M Zinkernagel
Aug 23, 2002·Immunological Reviews·Rolf M Zinkernagel
Jul 1, 1984·The American Journal of Anatomy·N M Le DouarinP D Oliver
May 14, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bin LiM Louise Markert
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Matthew T MenardJoren C Madsen
Jan 24, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L S KeanC P Larsen
Feb 2, 2006·Immunological Reviews·Marie-Eve BlaisClaude Perreault

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