Restrictive Spirometry Pattern, Cardiac Structure and Function, and Incident Heart Failure in African Americans. The Jackson Heart Study

Annals of the American Thoracic Society
Matthew JankowichGaurav Choudhary

Abstract

Although chronic obstructive pulmonary disease has been related to heart failure, the relationship between the restrictive spirometry pattern (forced vital capacity [FVC] < 80% predicted with preserved forced expiratory volume in 1 second [FEV1]/FVC ratio) and heart failure is poorly understood. To determine whether having a restrictive spirometry pattern is associated with incident heart failure hospitalization. Community-dwelling African Americans from the Jackson Heart Study (total n = 5,306; analyzed n = 4,210 with spirometry and heart failure outcome data) were grouped by restrictive spirometry (FEV1/FVC ≥ 0.70, FVC < 80%; n = 840), airflow obstruction (FEV1/FVC < 0.70; n = 341), and normal spirometry (FEV1/FVC ≥ 0.70, FVC ≥ 80%; n = 3,029) at the time of baseline examination in 2000-2004. We assessed relationships of echocardiographic parameters and biomarkers with spirometry patterns using regression models. Incident heart failure was defined as an adjudicated hospitalization for heart failure after January 1, 2005 in subjects with no self-reported heart failure history. We used multivariable-adjusted Poisson regression models and Cox proportional hazards models, with death treated as a competing risk in the Cox models, ...Continue Reading

References

Jun 1, 1974·Circulation·W B KannelW P Castelli
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·G GudmundssonD M Shasby
Sep 7, 2006·Statistics in Medicine·Michael J PencinaRalph B D'Agostino
Feb 26, 2008·American Heart Journal·Joana MascarenhasPaulo Bettencourt
Jun 10, 2008·Journal of Internal Medicine·K K IversenUNKNOWN ECHOS-Lung Function Study Group
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Mar 9, 2010·Journal of Cardiac Failure·Jonathan De BloisUNKNOWN Norwegian Heart Failure Registry
May 21, 2010·Respiratory Medicine·Luis A García RodríguezSaga Johansson
Sep 18, 2010·Cellular and Molecular Life Sciences : CMLS·Yoshifumi Kawanabe, Surya M Nauli
Mar 26, 2011·The American Journal of Medicine·Vasiliki V GeorgiopoulouJaved Butler
Apr 6, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·E C OelsnerR G Barr
Jun 25, 2013·Respiratory Medicine·Joy MillerUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Sep 4, 2013·Heart & Lung : the Journal of Critical Care·Armine G MinasianYvonne F Heijdra
Aug 7, 2014·Respiratory Research·Emily S WanUNKNOWN COPDGene Investigators
Jan 2, 2015·Circulation Research·Carlos M Ferrario, Ernesto L Schiffrin
Apr 16, 2015·American Journal of Respiratory and Critical Care Medicine·Michael J CutticaRavi Kalhan
Apr 22, 2016·International Journal of Chronic Obstructive Pulmonary Disease·Yoshiaki KubotaWataru Shimizu
May 31, 2016·International Journal of Cardiology·Christina BaumUNKNOWN Gutenberg Health Study investigators
Sep 21, 2016·Statistical Methods in Medical Research·Matthieu Resche-Rigon, Ian R White
Jan 8, 2017·BMC Pulmonary Medicine·Morten DalsgaardKasper Iversen
Mar 1, 2017·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S BektasH P Brunner-La Rocca

❮ Previous
Next ❯

Citations

Oct 12, 2019·The European Respiratory Journal·Sara Renata Alex WijnantGuy G Brusselle
Oct 3, 2018·Annals of the American Thoracic Society·Aparna Balasubramanian, Nirupama Putcha
Aug 12, 2021·American Journal of Respiratory and Critical Care Medicine·David M Mannino

❮ Previous
Next ❯

Software Mentioned

R
SAS
Stata

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.