Result of interferon-alpha therapy in patients with chronic myelogenous leukemia 60 years of age and older

The American Journal of Medicine
J CortesMoshe Talpaz

Abstract

To determine the response rate to interferon-alpha (IFN-alpha) in patients with chronic myelogenous leukemia (CML) aged 60 years and older. Patients with CML aged 60 years and older included in all protocols with INF-alpha therapy for chronic phase CML at the M.D. Anderson Cancer Center were analyzed. They were treated with human leukocyte or recombinant human IFN-alpha 5x10(6) U/m2 daily alone or in combination with hydroxyurea or IFN gamma. The clinical characteristics of the patients were analyzed and their hematologic and cytogenetic responses to IFN-alpha and survival from the initiation of therapy were determined. Results were compared with those of younger patients treated in the same protocols. Treatment-related toxicity was also analyzed. Thirty-five of 274 (13%) patients included in trials of IFN-alpha-based regimens for CML were 60 years and older. Older patients had a higher percentage of bone marrow blasts (P = 0.04) and basophils (P = 0.09) than younger patients. Sixty-nine percent achieved a complete hematologic remission with IFN-alpha therapy, and 51% had a cytogenetic response, which was major in 26% and complete (Philadelphia chromosome-positive cells = 0%) in 20%, Their median survival was 64 months, and the...Continue Reading

Citations

Feb 13, 2001·British Journal of Haematology·S J Lee
Jun 1, 1997·Baillière's Clinical Haematology·J CortesM Talpaz
Apr 2, 1998·Hematology/oncology Clinics of North America·H M KantarjianM Talpaz
Apr 1, 2011·Blood·Gabriele GugliottaUNKNOWN Gruppo Italiano Malattie Ematologiche dell'Adulto CML Working Party
Oct 29, 2003·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Masanori UmedaKimiko Iijima
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xin Shelley WangCharles S Cleeland
Sep 19, 2012·American Journal of Hematology·Philippe RousselotUNKNOWN French Intergroup For Chronic Myelogenous Leukemia (Fi-LMC)
Jun 3, 2021·Expert Review of Hematology·Massimo BrecciaMaurizio Martelli

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