Results after surgical treatment of liver metastases in patients with high-grade gastroenteropancreatic neuroendocrine carcinomas

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
R B GallebergHalfdan Sorbye

Abstract

Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce. The aim of this study was to evaluate the results of curatively intended resection/radiofrequency ablation (RFA) of liver metastases in patients with metastatic GEP-NEC. 32 patients with a diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasm (Ki-67 > 20%) and with intended curative resection/RFA of liver metastases, were identified among 840 patients from two Nordic GEP-NEC registries. Tumor morphology (well vs poor differentiation) was reassessed. Overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analyses for the entire cohort and for subgroups. Median OS after resection/RFA of liver metastases was 35.9 months (95%-CI: 20.6-51.3) with a five-year OS of 43%. The median PFS was 8.4 months (95%-CI: 3.9-13). Four patients (13%) were disease-free after 5 years. Two patients had well-differentiated morphology (NET G3) and 20 patients (63%) had Ki-67 ≥ 55%. A Ki-67 < 55% and receiving adjuvant chemo...Continue Reading

References

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Apr 26, 2014·Annals of Surgical Oncology·James D SmithGarrett M Nash
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Jan 6, 2016·Neuroendocrinology·R Garcia-CarboneroUNKNOWN Vienna Consensus Conference participants
Feb 9, 2016·Diagnostics·Emma Elizabeth IlettUlrich Knigge

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Citations

Sep 22, 2019·Cancers·Vincent LaroucheShereen Ezzat
Nov 14, 2019·Annals of Surgical Oncology·Elettra MerolaMarianne E Pavel
Jul 1, 2020·Zentralblatt für Chirurgie·Florian BöschJens Werner
Aug 21, 2019·Current Treatment Options in Oncology·Mohamad Bassam Sonbol, Thorvardur R Halfdanarson
Mar 14, 2019·Annals of Surgical Oncology·Tsukasa YoshidaNobumasa Mizuno
Oct 13, 2021·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Jisheng ZhuYong Li

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