Results and challenges of immune checkpoint inhibitors in colorectal cancer

Expert Opinion on Biological Therapy
Sheik EmambuxDavid Tougeron

Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and clinical outcome has improved substantially during the last two decades with targeted therapies. The immune system has a major role in cancers, especially the CD8 + T cells specific to tumor antigens. However, tumors can escape immune response by different mechanisms including upregulation of inhibitory immune checkpoint receptors, such as well-known Programmed cell Death protein-1 (PD-1)/Programmed cell Death Ligand 1 (PD-L1) interaction, leading CD8 + T cells to a state of anergy. Immunotherapy, with the so-called immune checkpoint inhibitors (CPIs), has recently been approved in treatment of multiple cancers due to its prolonged disease control and acceptable toxicities. The recent groundbreaking success involving anti-PD-1 CPIs in metastatic CRC with deficient mismatch repair system (dMMR) is promising, with several trials ongoing. Major challenges are ahead in order to determine how, when and for which patients we should use these CPIs in CRC. This review highlights some promises and challenges concerning personalized immunotherapy in CRC. First results and ongoing breakthrough trials are presented. The crucial role of biomarkers in selecting...Continue Reading

References

May 1, 1996·Tissue Antigens·M BrowningW Bodmer
Mar 13, 2001·Annual Review of Immunology·W R Heath, F R Carbone
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E KeoghA Sette
Jan 5, 2002·Cancer Immunology, Immunotherapy : CII·I SaeterdalG Gaudernack
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Benjamin Chun-Yu WongUNKNOWN China Gastric Cancer Study Group
Feb 6, 2004·Gastroenterology·John M CarethersC Richard Boland
Feb 19, 2004·Journal of the National Cancer Institute·Asad UmarSudhir Srivastava
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Nov 16, 2005·Nature Immunology·Chen ZhuVijay K Kuchroo
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Feb 21, 2006·Cancer Research·Iñigo TirapuIgnacio Melero
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Loris ZamaiMarco Vitale
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy J FrenchStephen N Thibodeau
Mar 5, 2009·Cancer Research·Matthieu CamusJérôme Galon
Jun 9, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David TougeronJean-Baptiste Latouche
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 28, 2010·Gastroenterology·Barbara Leggett, Vicki Whitehall
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ki Y ChungLeonard B Saltz
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J SargentSteven Gallinger
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernhard MlecnikJérôme Galon
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemFortunato Ciardiello
Jan 5, 2012·Journal of Translational Medicine·Jérôme GalonPaolo A Ascierto
Jan 25, 2012·Journal of the National Cancer Institute·Jun-Ling MaMitchell H Gail
Mar 9, 2012·The New England Journal of Medicine·Michael A PostowJedd D Wolchok
May 25, 2012·The New England Journal of Medicine·Susan M HinikerSusan J Knox
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Oct 5, 2012·Journal of Translational Medicine·Jérôme GalonBernard A Fox
Mar 13, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Raoul A DroeserLuigi Tornillo
Mar 19, 2013·Bulletin du cancer·David TougeronJean-Baptiste Latouche
Jun 4, 2013·The New England Journal of Medicine·Jedd D WolchokMario Sznol
Jun 5, 2013·Frontiers in Oncology·Sandra Demaria, Silvia C Formenti
Jun 14, 2013·Familial Cancer·Magnus von Knebel Doeberitz, Matthias Kloor
Aug 7, 2013·Cancer Prevention Research·Edmond MarzbaniMary L Disis
Oct 18, 2013·Nature Reviews. Cancer·Robert F Schwabe, Christian Jobin
Jan 3, 2014·The Journal of Clinical Investigation·Liufu DengYang-Xin Fu
Apr 3, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria-Gabriela AniteiFranck Pagès
Aug 8, 2014·Oncoimmunology·Florence Boissière-MichotFrédéric Bibeau

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Citations

Nov 2, 2018·Expert Review of Anticancer Therapy·Per PfeifferCamilla Qvortrup
Jan 5, 2020·International Journal of Cancer. Journal International Du Cancer·Jiabo DiXiangqian Su
Jan 22, 2020·Journal of Cellular Physiology·Zahra PayandehBehzad Baradaran
May 27, 2020·British Journal of Cancer·Anita L RayKatherine T Morris
Jul 15, 2020·Molecular Biology Reports·Parastoo ShakerinMaryam Nourizadeh
Oct 5, 2018·BMC Cancer·Ramón Cantero-CidEduardo López-Collazo
Jun 9, 2020·Frontiers in Immunology·Stuart P BerzinsJason Kelly
Jul 29, 2020·Cancer Immunology, Immunotherapy : CII·Chunxia ZhangWeipeng Wang
Jan 23, 2019·Cancer Immunology Research·Hadar ReichmanAriel Munitz
Dec 17, 2020·Frontiers in Cell and Developmental Biology·Nadiah AbuRahman Jamal
Jun 3, 2021·Vaccines·Benjamin WolfsonJames W Hodge
May 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junli XueWei Peng
Nov 18, 2021·Cancer Immunology Research·Liane BabesPaul Kubes
Jan 14, 2022·Journal of Comparative Effectiveness Research·Chunhui JinJianliang You

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