Results dissemination from clinical trials conducted at German university medical centres was delayed and incomplete

BioRxiv : the Preprint Server for Biology
Susanne WieschowskiDaniel Strech

Abstract

Objective: Timely and comprehensive reporting of clinical trial results build the backbone of evidence-based medicine and responsible research. The proportion of timely disseminated trial results can inform alternative national and international benchmarking of university medical centers (UMCs). Study Design and Setting: For all German UMCs we tracked all registered trials completed between 2009 and 2013. The results and an interactive website benchmark German UMCs regarding their performance in results dissemination. Results: We identified and tracked 2,132 clinical trials. For 1,509 trials, one of the German UMCs took the academic lead. Of these 1,509 "lead trials", 39% published their results (mostly via journal publications) in a timely manner (<24 months after completion). More than six years after study completion, 26% of all eligible lead trials still had not disseminated results. Conclusion: Despite substantial attention from many stakeholders to the topic, there is still a strong delay or even absence of results dissemination for many trials. German UMCs have several opportunities to improve this situation. Further research should evaluate whether and how a transparent benchmarking of UMC performance in results dissemi...Continue Reading

Related Concepts

Academic Medical Centers
Clinical Trials
Pharmaceutical Preparations
Research
Research Design
Central
Disseminated
Academia (Organization)
Health Care Organization
Study

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