Results from pelvic exenteration for locally advanced colorectal cancer with lymph node metastases

Diseases of the Colon and Rectum
J HidaK Fujimoto

Abstract

We examined the survival benefit of pelvic exenteration for locally advanced colorectal cancer with lymph node metastases, because this issue remains controversial. Medical records of 50 patients who underwent curative pelvic exenteration for colorectal cancer were reviewed retrospectively. Nodal metastases were examined by the clearing method in 29 patients and by the conventional manual method in 21 patients. Invasion to contiguous pelvic organs was present in 40 patients (80 percent) and absent in 10 patients (20 percent). Node metastases were present in 33 patients (66 percent). Operative morbidity and mortality rates were 22 percent (11 patients) and 6 percent (3 patients), respectively. Respective five-year survival rates were 60 and 80 percent in the groups with and without organ invasion (no significant difference). Five-year survival rates in patients with nodal metastases was 54.6 percent but was significantly higher, 82.4 percent, in patients without nodal metastases. Five-year survival in 28 patients with both organ invasion and nodal metastases was 53.6 percent. Long-term survival was afforded by pelvic exenteration for locally advanced colorectal cancer with nodal metastases.

References

Jun 1, 1992·American Journal of Surgery·S A CurleyF C Ames
Jan 1, 1992·Annals of Surgery·G H HafnerN J Petrelli
Jul 1, 1987·American Journal of Surgery·J A HunterP Schultz
Apr 1, 1989·Diseases of the Colon and Rectum·B A OrkinD M Ilstrup
May 1, 1987·Diseases of the Colon and Rectum·F P GallA Altendorf
May 1, 1982·Archives of Surgery·T P McGloneD W Elliott
Jun 1, 1982·The British Journal of Surgery·G BonfantiL Gennari
Oct 1, 1995·The British Journal of Surgery·M PoezeM F von Meyenfeldt
Dec 1, 1995·Diseases of the Colon and Rectum·J R IzbickiC E Broelsch
Feb 1, 1994·Diseases of the Colon and Rectum·S Y LiuH Fu
Jan 1, 1996·The British Journal of Surgery·K ShirouzuT Kakegawa

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Citations

Oct 3, 1999·Seminars in Surgical Oncology·P J CroweA S Ketcham
Nov 7, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D M KecmanovicA B Stamenkovic
Jul 31, 2001·Surgical Oncology·A R Sasson, E R Sigurdson
Feb 17, 2000·Surgical Oncology·L Ruo, J G Guillem
Oct 19, 2006·Journal of the National Cancer Institute·Anand GovindarajanCalvin H L Law
Apr 25, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G C BannuraJ E Mansilla
Nov 6, 2004·International Seminars in Surgical Oncology : ISSO·K HarishS Nirmala
Mar 16, 2006·Annals of Surgical Oncology·Timothy M PawlikMiguel A Rodriguez-Bigas
May 15, 2013·Annals of Surgical Oncology·H M MohanD C Winter
Sep 24, 2011·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Trustin S DomesJonathan I Izawa
Nov 20, 2013·Langenbeck's Archives of Surgery·D CourtneyD C Winter
Aug 13, 2014·ANZ Journal of Surgery·Greg A TurnerFrank A Frizelle
Jan 7, 2000·Journal of the American College of Surgeons·W L LawH K Choi
Jan 4, 2006·Surgical Oncology Clinics of North America·Seung-Yong JeongJose G Guillem
Jul 7, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S G LarsenK-E Giercksky
Jul 9, 2004·Surgical Oncology Clinics of North America·Farin AmersiClifford Y Ko
Oct 9, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y SunX Wang
Oct 27, 2016·World Journal of Surgical Oncology·Aki TakiyamaToshiaki Watanabe
Mar 5, 2008·Arquivos De Gastroenterologia·Sergio Renato Pais CostaRenato Arioni Lupinacci
Aug 14, 2020·The British Journal of Surgery·Q DenostF Saillour-Glénisson
Dec 17, 2011·Bulletin du cancer·Jean-Jacques TuechFrancis Michot

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