Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis

Antimicrobial Agents and Chemotherapy
Hakan ErdemHaluk Vahaboglu

Abstract

Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.

References

Dec 1, 1992·Statistics in Medicine·W Sauerbrei, M Schumacher
Jan 16, 1986·The New England Journal of Medicine·R J WhitleyS J Soong
Jul 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Franck RaschilasFlore Rozenberg
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelRichard J Whitley
Aug 7, 2007·Neuropsychological Rehabilitation·Stephen M PewterJanice M Kay
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anders HjalmarssonBirgit Sköldenberg
Jun 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelUNKNOWN Infectious Diseases Society of America
Aug 6, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ugo K IhekwabaMichael W McKendrick
Mar 25, 2009·Enfermedades infecciosas y microbiología clínica·Antoni Riera-MestrePedro Fernández-Viladrich
Jun 30, 2009·The American Journal of Medicine·Marie L LandryHolenarasipur R Vikram
Sep 8, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H ErdemUNKNOWN Members of the Turkish Bacterial Meningitis in the Elderly Study Group*
Nov 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexandra MaillesUNKNOWN Steering Committee and Investigators Group
Jul 27, 2010·QJM : Monthly Journal of the Association of Physicians·B D MichaelUNKNOWN North West Neurological Infections Network
Apr 8, 2011·Epidemiology and Infection·J P StahlUNKNOWN Steering Committee and Investigators Group
Nov 29, 2011·The Journal of Infection·T SolomonUNKNOWN National Encephalitis Guidelines Development and Stakeholder Groups
Aug 29, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·N ChildN E Anderson
Nov 12, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hakan ErdemHaluk Vahaboglu
Apr 29, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Uluhan SiliUNKNOWN HSV Encephalitis Study Group
Oct 4, 2014·SpringerPlus·Heiður Mist DagsdóttirSigurður Guðmundsson
Oct 11, 2014·The Cochrane Database of Systematic Reviews·Sanjay PandeyBenedict D Michael

❮ Previous
Next ❯

Citations

Apr 18, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y CagN Elaldi
Aug 1, 2016·Emergency Medicine Clinics of North America·Stephen Y Liang
Oct 9, 2016·The Journal of Infection·Laura Krogh JørgensenTrine Hyrup Mogensen
Dec 22, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O Ergonul, S Keske
Feb 2, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H Erdem, Y Cag
Mar 21, 2017·Médecine et maladies infectieuses·P FillatreM Lecuit
Feb 14, 2018·Journal of Clinical Microbiology·Rachael M LiesmanMatthew J Binnicker
Dec 9, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I N HakyemezY Cag
Aug 9, 2018·The New England Journal of Medicine·Kenneth L Tyler
Feb 19, 2016·Journal of Clinical Microbiology·Christopher R Polage, Stuart H Cohen
Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Kelly J Baldwin, Christopher L Cummings
Oct 30, 2019·Future Microbiology·Yueying HuangMinjie Yang
Mar 3, 2017·Current Infectious Disease Reports·John W Gnann, Richard J Whitley
Dec 12, 2018·The Pediatric Infectious Disease Journal·Rodrigo HasbunChristine C Ginocchio
Mar 10, 2019·Journal of Neurovirology·Bethany L BrownJ David Beckham
Feb 14, 2020·Clinical Microbiology Reviews·Jocelyne Piret, Guy Boivin
May 19, 2017·Journal of Neurology·S ModiP Mitsias
Apr 12, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H ErdemM Nassar
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Shalini Gundamraj, Rodrigo Hasbun
Apr 29, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Le BotPierre Tattevin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Tijdschrift voor ziekenverpleging
E J Kompanje
The Professional Nurse
M Watson
The American Journal of Nursing
C Jones
Österreichische Krankenpflegezeitschrift
C Jones
© 2021 Meta ULC. All rights reserved