PMID: 9184629Jun 1, 1997Paper

Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations

Journal of Neuroimmunology
D B WilsonD P Gold

Abstract

To identify a panel of multiple sclerosis patients (MS) for a phase I clinical trial of a T-cell receptor (TCR) peptide vaccine we characterized the T-cell populations present in the cerebrospinal fluids (CSF) of a large group of patients with respect to surface phenotype and state of activation, TCR beta chain utilization, features of the CDR3 junctional region, the extent of clonality and persistence of selected clonotypes over time. These CSF cell populations consist of approximately 60% CD4+ T-cells, half of which bear IL-2 receptors, indicating these activated T-cells may be part of the pathogenic process in MS. When these activated CD4+ T-cells were selectively expanded in IL-2/IL-4 supplemented cultures, an over-representation of several TCRV beta families was noted in 39/47 patients, the most frequent being V beta 6.5, V beta 6.7, V beta 2, V beta 5 and V beta 4. Biased expression of various members of the V beta 6 family was seen in 21 of this group of 39 patients. Clonal analysis of TCR beta 6 CDR3 sequences, revealed two notable features: clonal dominance and clonal persistence. CSF cells from two-thirds of MS patients contained a dominant clone comprising 50% or more of sequences and the same patient-specific clone ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Feb 1, 1989·European Journal of Immunology·J ChlubaJ T Epplen
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B ToyonagaT W Mak
Mar 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·B H Waksman, W E Reynolds
Nov 4, 1982·The New England Journal of Medicine·D E McFarlin, H F McFarland
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
May 1, 1995·The Journal of Experimental Medicine·A BenderR Hohlfeld
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C ChangD J Carlo
Mar 1, 1994·The Journal of Experimental Medicine·C M WeyandJ J Goronzy
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A A GromD N Glass
Dec 11, 1997·Scandinavian Journal of Immunology·M Jeddi-TehraniR Andersson

❮ Previous
Next ❯

Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·F C JensenJ C Chang
Oct 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R N HeardG J Stewart
Jul 14, 2007·The Journal of Clinical Investigation·Juscilene S MenezesEli E Sercarz
Jul 10, 2008·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Arthur A Vandenbark, Rivka Abulafia-Lapid
Aug 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reinhard Hohlfeld, Hartmut Wekerle
Oct 23, 1997·Journal of Neuroimmunology·R M NagraW F Reynolds
May 14, 2011·Cytometry. Part B, Clinical Cytometry·Marieke T de GraafJan W Gratama
Dec 30, 1999·International Reviews of Immunology·H Offner, A A Vandenbark
Dec 2, 2005·International Reviews of Immunology·Mireia Sospedra, Roland Martin
Jul 2, 2005·Expert Opinion on Investigational Drugs·E G Spack
Oct 8, 1998·Multiple Sclerosis : Clinical and Laboratory Research·P StinissenJ Raus
Nov 1, 2008·Nature Reviews. Drug Discovery·Rocio S Lopez-Diego, Howard L Weiner
Jan 5, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Hiroaki Niiro
Jan 5, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Masakazu NakamuraTakashi Yamamura
Jan 5, 2006·Autoimmunity·Erica Lee, Animesh A Sinha
Nov 12, 1998·Arthritis and Rheumatism·B L Kotzin, J Kappler
Nov 9, 2002·Journal of Clinical Periodontology·R E PerssonG R Persson
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·D N BourdetteA A Vandenbark
Jul 17, 1998·Clinical and Diagnostic Laboratory Immunology·S N Liossis, G C Tsokos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M LewańskaK Selmaj
JAMA : the Journal of the American Medical Association
J R OksenbergL Steinman
© 2021 Meta ULC. All rights reserved