PMID: 8948352Oct 1, 1996Paper

Results of a phase II trial of external beam radiation with etanidazole (SR 2508) for the treatment of locally advanced prostate cancer (RTOG Protocol 90-20)

International Journal of Radiation Oncology, Biology, Physics
C A LawtonM Rotman

Abstract

RTOG Protocol 90-20 was designed to evaluate the effect of the hypoxic cell sensitizer Etanidazole (SR-2508) on locally advanced adenocarcinoma of the prostate treated with concurrent external beam irradiation. Patients with biopsy-proven adenocarcinoma of the prostate with locally advanced T2b, T3, and T4 tumors were eligible for this study. No patients with disease beyond the pelvis were eligible. Serum prostate specific antigen (PSA) was mandatory. All patients received definitive external beam irradiation using standard four-field whole pelvis treatment to 45-50 Gy, followed by a cone down with a minimum total dose to the prostate of 66 Gy at 1.8-2.0 Gy/fraction over 6.5-7.5 weeks. Etanidazole was delivered 1.8 g/m2 given 3 times a week to a total of 34.2 g/m2 or 19 doses. Thirty-nine patients were entered onto the study. Three patients refused treatment; therefore, 36 patients were eligible for further evaluation. Median follow-up was 36.9 months from treatment end. All patients had elevated initial PSA levels, and 18 patients had PSAs of > 20 ng/ml. Tumor classification was T2, 12 patients (33.3%); T3, 22 patients (61.1%); and T4, 2 patients (5.6%). Complete clinical response, defined as PSA < 4 ng/ml and complete clinica...Continue Reading

References

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Jun 15, 1994·International Journal of Radiation Oncology, Biology, Physics·C BeardC N Coleman

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Citations

Jan 1, 1996·Urologic Oncology·C N Coleman, M A Stevenson
Mar 29, 2003·Journal of Biomaterials Science. Polymer Edition·Fang-Jing Wang, Chi-Hwa Wang
Apr 22, 2008·The Cochrane Database of Systematic Reviews·M A HorneberM Rostock
Jun 12, 2002·Journal of Radiation Research·Mikinori KuwabaraMichihiko Tsujitani
Dec 12, 2001·Current Problems in Cancer·M M PoggiJ B Mitchell

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