Results of a prospective randomized trial with neoadjuvant chemotherapy in stage IB, bulky, squamous carcinoma of the cervix

Gynecologic Oncology
J E SardiC Vico

Abstract

A prospective randomized trial was carried out in patients with squamous carcinoma of the cervix uteri, stage Ib bulky. The protocol considers two arms: the control group (75 patients) and the neoadjuvant one (76 patients). All the patients were classified according to the FIGO staging system and in order to determine the tumor size objectively, an ultrasound scanning was done. After this a Wertheim-Meigs operation followed by adjuvant whole-pelvis irradiation was performed. In the neoadjuvant group the same procedures were carried out but three courses of chemotherapy with the "quick" VBP scheme were given before the treatment. The new therapeutic strategy proved to be very useful in bulky tumors in which the clinical examination showed a cervix increased in size and the ultrasound scanning a volume larger than 60 c.c. (> 4 x 4 x 4 cm). In those cases statistically significant differences were found between both groups when free disease interval and survival were considered. These were due to the fact that operability has been improved and the parametrial extension has been decreased as well as other risk factors such as vascular embolism, lymph node involvement, tumor-cervix quotient, and tumor volume. The use of this new str...Continue Reading

Citations

Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. G. EtcheverryA. Nuñez De Pierro
Mar 27, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H-J HuangC-H Lai
Apr 18, 1996·The New England Journal of Medicine·S A Cannistra, J M Niloff
Jul 15, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K Narayan
Sep 25, 2015·Expert Review of Anticancer Therapy·Mariateresa LapresaNicoletta Colombo
Jul 31, 2012·Gynecologic Oncology·Lua Eiriksson, Allan Covens
Dec 13, 2007·Gynecologic Oncology·Juan E Sardi
Nov 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Chel Hun ChoiDuk-Soo Bae
Aug 31, 2007·Gynecologic Oncology·Pieluigi Benedetti PaniciRoberto Angioli
Aug 17, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J QinX Xie
Jun 2, 1998·Cancer Treatment Reviews·S PignataS Monfardini
Mar 18, 1999·Hematology/oncology Clinics of North America·K GrevenR Lanciano
May 1, 1997·Gynecologic Oncology·E SerurJ C Remy
Jul 19, 2013·Gynecologic Oncology·Clare J ReadeAllan Covens
Oct 26, 2000·The Journal of Obstetrics and Gynaecology Research·S J Kim
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierluigi Benedetti-PaniciFabio Landoni
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H-S RyuJ-H Kim
Jul 25, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dae Woo LeeHae Nam Lee
Aug 7, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alejandro M AragonaSilvia Lekmann
Oct 31, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alexandros RodolakisDimitrios Loutradis
Jun 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hiroshi TsubamotoShozo Hirota
Jun 13, 2006·The Journal of Obstetrics and Gynaecology Research·Hong-Bing CaiHou-Han Yin
Mar 5, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Kyung-Do KiSeon-Kyung Lee
Feb 19, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hae Nam LeeJong Sup Park
Aug 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taisuke MoriJo Kitawaki
Apr 10, 2007·Topics in Magnetic Resonance Imaging : TMRI·Camilla R Whitten, Nandita M DeSouza
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Han-Lin ShuaiDan-Liang Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.