Results of a randomized trial comparing sequential intravenous/oral treatment with ciprofloxacin plus metronidazole to imipenem/cilastatin for intra-abdominal infections. The Intra-Abdominal Infection Study Group

Annals of Surgery
J S SolomkinR M Echols

Abstract

In a randomized, double-blind, multicenter trial, ciprofloxacin/metronidazole was compared with imipenem/cilastatin for treatment of complicated intra-abdominal infections. A secondary objective was to demonstrate the ability to switch responding patients from intravenous (IV) to oral (PO) therapy. Intra-abdominal infections result in substantial morbidity, mortality, and cost. Antimicrobial therapy often includes a 7- to 10-day intravenous course. The use of oral antimicrobials is a recent advance due to the availability of agents with good tissue pharmacokinetics and potent aerobic gram-negative activity. Patients were randomized to either ciprofloxacin plus metronidazole intravenously (CIP/MTZ IV) or imipenem intravenously (IMI IV) throughout their treatment course, or ciprofloxacin plus metronidazole intravenously and treatment with oral ciprofloxacin plus metronidazole when oral feeding was resumed (CIP/MTZ IV/PO). Among 671 patients who constituted the intent-to-treat population, overall success rates were as follows: 82% for the group treated with CIP/MTZ IV; 84% for the CIP/MTZ IV/PO group; and 82% for the IMI IV group. For 330 valid patients, treatment success occurred in 84% of patients treated with CIP/MTZ IV, 86% of...Continue Reading

References

Jan 1, 1992·Chemotherapy·M A Bayles
Dec 1, 1992·Antimicrobial Agents and Chemotherapy·B BrismarT Skau
Nov 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S SolomkinJ Bartlett
Nov 11, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T R BeamC M Kunin
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·R W FrostJ T Lettieri
May 1, 1992·Antimicrobial Agents and Chemotherapy·J T LettieriA H Heller
Sep 11, 1991·Reviews of Infectious Diseases·D N GilbertC M Kunin
Aug 1, 1990·Annals of Surgery·P S BarieJ P Waymack
Feb 1, 1990·Annals of Surgery·R S BennionS M Finegold
Jul 1, 1985·Antimicrobial Agents and Chemotherapy·R L DavisA L Smith
Mar 1, 1985·Antimicrobial Agents and Chemotherapy·B LedergerberR Lüthy
Mar 1, 1985·Antimicrobial Agents and Chemotherapy·G HöffkenP Koeppe
May 1, 1988·Archives of Disease in Childhood·J P Roberts
May 1, 1988·Reviews of Infectious Diseases·H ThadepalliV K Dhawan
Jul 1, 1986·The Journal of Antimicrobial Chemotherapy·U GanzingerG Gumhold
Aug 1, 1983·The Journal of Infectious Diseases·P N HeseltineT V Berne
Mar 1, 1983·Archives of Surgery·J BohnenA P McLean
Oct 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T R BeamC M Kunin

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Gastroenterology Reports·Z Younes, D A Johnson
Jun 16, 2005·International Journal of Antimicrobial Agents·Andries GousHeino Stass
Dec 1, 1996·American Journal of Surgery·A B Nathens, O D Rotstein
Feb 6, 1999·American Journal of Surgery·J A Weigelt
Oct 19, 2002·International Journal of Antimicrobial Agents·Albert E YellinUNKNOWN 004 Intra-abdominal Infection Study Group
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D C Hooper
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary E Stein, Ellie J C Goldstein
Feb 22, 2003·Surgical Infections·D E Fry, C R Schermer
Feb 22, 2003·Surgical Infections·R L Nichols
Feb 22, 2003·Surgical Infections·P S BarieS E Wilson
Jan 25, 2003·Surgical Infections·John E MazuskiUNKNOWN Therapeutic Agents Committee of the Surgical Infections Society
Jan 25, 2003·Surgical Infections·John E MazuskiUNKNOWN Therapeutic Agents Committee of the Surgical Infections Society
Oct 6, 2005·Surgical Infections·Jose M Tellado, Samuel E Wilson
Feb 20, 2009·Surgical Infections·Matthew C Byrnes, John E Mazuski
Mar 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinJon B Bruss
Apr 30, 2009·The Journal of Antimicrobial Chemotherapy·Dominik MertzStefano Bassetti
Apr 9, 2001·Critical Care Medicine·J S Solomkin
Jun 3, 2009·Critical Care Medicine·John C MarshallUNKNOWN International Sepsis Forum
Jul 6, 2012·Clinical Microbiology Reviews·Pranita D TammaLisa L Maragakis
Nov 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Thomas G Slama
May 10, 2007·Drugs·George G ZhanelJames A Karlowsky
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinUNKNOWN Infectious Diseases Society of America
Feb 18, 2014·The Journal of Antimicrobial Chemotherapy·Marjorie M ConantDanielle Osterholzer
Mar 13, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P KujathA Rodloff
Jun 16, 2005·Expert Review of Anti-infective Therapy·Rainer Isenmann, Doris Henne-Bruns
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Ioannis P KioumisDavid P Nicolau

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