Results of a thirty-year study of familial adenomatous polyposis coli

Diseases of the Colon and Rectum
A M NikitinA V Jakushin

Abstract

This study was designed to estimate the efficiency of the various methods used to treat familial adenomatous polyposis coli. Three hundred ninety patients (219 males) underwent surgery for familial adenomatous polyposis coli; postoperative follow-up was from 1 to 30 years. Coloproctectomy with preservation of the anal sphincter and coloproctectomy with ileoanal pull-through procedures resulted in development of anal canal cancer in 3 (4.1 percent) of 74 patients. Follow-up revealed development of cancer in the large bowel in 26 (10.7 percent) of 242 patients, in whom colectomy with preservation of various colonic segments was performed. The occurrence rate of cancer is not significantly related to patients' gender, age, length of preserved colonic segment, presence of cancer in the removed colonic segment, or postoperative follow-up period; however, presence of polyps in the colonic segments preserved during surgery significantly increased the risk of development of cancer at a later time.

References

Jan 1, 1979·American Journal of Surgery·B S GingoldR B Turnbull
Jan 1, 1977·Cancer·J J DeCosseR E Condon
Jan 1, 1989·International Journal of Colorectal Disease·T OreslandL Hultén
Oct 1, 1988·Scandinavian Journal of Gastroenterology·R EmblemS Larsen
Jun 1, 1987·Diseases of the Colon and Rectum·T M HeimannA R Beck
Aug 1, 1972·American Journal of Surgery·W C Schaupp, P A Volpe
Jul 1, 1971·Cancer·C G MoertelM A Adson
Oct 1, 1980·Diseases of the Colon and Rectum·J UtsunomiyaR Hirayama
Apr 1, 1980·Archives of Surgery·M A BessC G Moertel

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.