Results of an artificial-lung survey to lung transplant program directors

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Jonathan W HaftRobert H Bartlett

Abstract

Lung transplantation is the only treatment for patients with end-stage lung disease. However, the scarcity of donor organs illustrates the need for alternatives. Recent success in the use of ventricular assistance has stimulated research in technology designed as a bridge to lung transplantation. Some laboratories have demonstrated significant advances in the development of artificial lungs, and clinical applications are on the horizon. In preparation, we sought to gather information from the lung transplant community regarding issues related to testing and potential trials of artificial lungs. We constructed a survey and distributed it to lung transplant program directors recognized by the United Network for Organ Sharing. Topics included required animal studies, preferred designs, logistics of clinical trials, and patient diagnoses most appropriate for such a trial. The 31 programs responding to the survey performed 72% of all lung transplants in the United States in 1999. Ninety-seven percent supported a Phase I trial using an artificial lung as a bridge to lung transplantation. Additionally, 58% specifically supported a trial in which organ allocation would be prioritized to enrolled patients. Idiopathic pulmonary fibrosis ...Continue Reading

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Citations

Aug 7, 2003·The Annals of Thoracic Surgery·Daniel G TangNeri M Cohen
Feb 7, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Scott D Lick, Joseph B Zwischenberger
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