Results of an investigator-initiated single-blind split-face comparison of photodynamic therapy and 5% imiquimod cream for the treatment of actinic keratoses

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Jason HadleyMichael Hadley

Abstract

Topical photodynamic therapy (PDT) with aminolevulinic acid (ALA) and 5% imiquimod cream are effective therapies for the treatment of actinic keratoses (AKs), but no split-face studies directly comparing these treatment options are available in the literature. To compare the efficacy and tolerability of ALA-PDT and imiquimod 5% cream for the treatment of AKs. Sixty-one patients were enrolled from the Salt Lake City Veterans Affairs Hospital; 51 completed the study and were included in the analysis. All patients were randomized to receive half of a sachet of imiquimod 5% cream twice weekly on half of their face and two sessions of PDT with 20% solution of ALA applied for 1 hour to the other side of the face. The 75% AK clearance rate was 34.6% for ALA-PDT and 25% for imiquimod 5% cream (p = .30). The mean reduction in AK count was 59.2% for ALA-PDT and 41.4% for imiquimod 5% cream (p = .002). Dermatology Life Quality Index (DLQI) scores were assessed for each treatment modality at week 4 and were 1.95 and 1.38, respectively (p = .20). The sample size was small, and patients applied a small amount of imiquimod 5% cream (half a sachet) to a large surface area. There was no statistically significant difference in treatment response...Continue Reading

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Citations

Feb 27, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jeffrey B TraversAlly-Khan Somani
Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kate RossNeil Fenske
Mar 15, 2014·Dermatology and Therapy·Annabel DoddsStephen Shumack
Apr 24, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·E SotiriouD Ioannides
Jul 2, 2015·Actas dermo-sifiliográficas·E Jubert-EsteveM Jones-Caballero
Aug 15, 2012·Expert Opinion on Pharmacotherapy·Brian Berman, Sadegh Amini
Apr 8, 2016·The Journal of Dermatological Treatment·William C HankeStephen Stone
Feb 5, 2005·Journal of the American Academy of Dermatology·Arun K ChakrabartyNancy J Anderson
Dec 19, 2012·Journal of the American Academy of Dermatology·Roger I Ceilley, Joseph L Jorizzo
Oct 27, 2016·Cancers·Liezel L Griffin, John T Lear
Jan 18, 2017·The British Journal of Dermatology·D de BerkerB R Hughes
Sep 11, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Andrea WilleyFernanda H Sakamoto
May 16, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Anthony J DixonHoward K Steinman
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Dec 20, 2020·Nature Reviews. Rheumatology·Simon FillatreauThomas Dörner

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